Lung simulation – an alternative approach to animal testing for applications in aerosol and respiratory research

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F18%3APU144035" target="_blank" >RIV/00216305:26220/18:PU144035 - isvavai.cz</a>

Výsledek na webu

<a href="https://proceedings.altex.org/data/2018-02/Linz-2018_webversion_a.pdf" target="_blank" >https://proceedings.altex.org/data/2018-02/Linz-2018_webversion_a.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Lung simulation – an alternative approach to animal testing for applications in aerosol and respiratory research

Popis výsledku v původním jazyce

Current developments in legal provisions and humane experimental procedures have shown the necessity of increasing the number of opportunities for alternatives to animal testing procedures. This topic especially seems challenging when a generic environmental factor, like ubiquitous aerosols, are taken into account. Approaches in aerosol and respiratory research, allowing conclusions on deposition and actually inhaled and exhaled particle number concentrations, have to be developed into this area as well. The xPULM simulator shall close the gap from already existing and well established procedures and experimental setups from the field of numerical simulation, over mechanical simulation approaches to in vitro procedures. All of the named test methodologies allow very specific and comprehensive research on effects of aerosol inhalation, but lack information on an organ scale level. The active breathing lung simulator xPULM, aims to bridge this gap by allowing multiple lung equivalents, like latex bags a

Název v anglickém jazyce

Lung simulation – an alternative approach to animal testing for applications in aerosol and respiratory research

Popis výsledku anglicky

Current developments in legal provisions and humane experimental procedures have shown the necessity of increasing the number of opportunities for alternatives to animal testing procedures. This topic especially seems challenging when a generic environmental factor, like ubiquitous aerosols, are taken into account. Approaches in aerosol and respiratory research, allowing conclusions on deposition and actually inhaled and exhaled particle number concentrations, have to be developed into this area as well. The xPULM simulator shall close the gap from already existing and well established procedures and experimental setups from the field of numerical simulation, over mechanical simulation approaches to in vitro procedures. All of the named test methodologies allow very specific and comprehensive research on effects of aerosol inhalation, but lack information on an organ scale level. The active breathing lung simulator xPULM, aims to bridge this gap by allowing multiple lung equivalents, like latex bags a

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20601 - Medical engineering

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů