Characteristic Waveforms for Testing of Medical Aerosol Inhalers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F20%3APU141506" target="_blank" >RIV/00216305:26220/20:PU141506 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.springerprofessional.de/en/characteristic-waveforms-for-testing-of-medical-aerosol-inhalers/18638550" target="_blank" >https://www.springerprofessional.de/en/characteristic-waveforms-for-testing-of-medical-aerosol-inhalers/18638550</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-030-64610-3_28" target="_blank" >10.1007/978-3-030-64610-3_28</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Characteristic Waveforms for Testing of Medical Aerosol Inhalers

Popis výsledku v původním jazyce

Respiratory diseases are characterised by high prevalence among the European population. Medical aerosol inhalers are the most commonly used means of drug delivery into the human respiratory system. This paper focuses on characteristic waveforms that can be utilised during aerosol deposition studies to simulate conditions of rapid human inhalation. Additionally, an inhalatory waveform based on clinically recorded spirometry data is introduced. Experimental measurements are performed and simulation results mutually compared using the electro-mechanical lung simulator xPULM™. The inhalatory waveforms are repeatably simulated with high fidelity in regards to the waveform shape with the lowest value of the Goodness of fit 0.89. Additionally, the measured values for all characteristic inhalatory parameters are simulated with low standard deviation σ < 1. The differences between the required and measured waveform shapes are small, ΔPIF < 3 L/min and do not influence the overall inhalatory volume. This opens a possibility of utilising the xPULM for medical aerosol inhalers testing.

Název v anglickém jazyce

Characteristic Waveforms for Testing of Medical Aerosol Inhalers

Popis výsledku anglicky

Respiratory diseases are characterised by high prevalence among the European population. Medical aerosol inhalers are the most commonly used means of drug delivery into the human respiratory system. This paper focuses on characteristic waveforms that can be utilised during aerosol deposition studies to simulate conditions of rapid human inhalation. Additionally, an inhalatory waveform based on clinically recorded spirometry data is introduced. Experimental measurements are performed and simulation results mutually compared using the electro-mechanical lung simulator xPULM™. The inhalatory waveforms are repeatably simulated with high fidelity in regards to the waveform shape with the lowest value of the Goodness of fit 0.89. Additionally, the measured values for all characteristic inhalatory parameters are simulated with low standard deviation σ < 1. The differences between the required and measured waveform shapes are small, ΔPIF < 3 L/min and do not influence the overall inhalatory volume. This opens a possibility of utilising the xPULM for medical aerosol inhalers testing.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

20601 - Medical engineering

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

8th European Medical and Biological Engineering Conference

ISBN

978-3-030-64609-7

ISSN

1680-0737

e-ISSN

—

Počet stran výsledku

6

Strana od-do

240-246

Název nakladatele

Springer Science and Business Media Deutschland GmbH

Místo vydání

neuveden

Místo konání akce

Tampere

Datum konání akce

11. 6. 2017

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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