Epicardial delivery of diversified pulsed field potentials in animal model
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F19%3APU132738" target="_blank" >RIV/00216305:26220/19:PU132738 - isvavai.cz</a>
Výsledek na webu
—
DOI - Digital Object Identifier
—
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Epicardial delivery of diversified pulsed field potentials in animal model
Popis výsledku v původním jazyce
Ablation of arrhythmias is based on thermal energy methods, radiofrequency and cryoablation. Despite high success rate, thermal character limits lesion formation control and may affect esophagus, phrenic nerve, and lungs. Non thermal irreversible electroporation (IRE) is inducing apoptotic cell death, is tissue-specific and effective. The comparison between AC/DC energy sources has not been systematically approached, clinically relevant parameters are yet to be validated. Methods: 12 farm pigs (female, 6m old, 45-55kg) underwent thoracotomy and epicardial IRE shock delivery. Square DC/AC pulse generators were connected to planar stainless-steel electrode (6x6mm) in a suction cup for tissue adherence, versus reference patch on the animal back (ca. 40cm from heart). High voltage AC/DC pulses (10 and 2 animals, 100 µs, 60 pulses, each set of 400, 600 and 800 V) were delivered in myorelaxation, at target frequency 80/min. in 3x3 grid application on left ventricle and 2*2 grid on left atrium, marked by sur
Název v anglickém jazyce
Epicardial delivery of diversified pulsed field potentials in animal model
Popis výsledku anglicky
Ablation of arrhythmias is based on thermal energy methods, radiofrequency and cryoablation. Despite high success rate, thermal character limits lesion formation control and may affect esophagus, phrenic nerve, and lungs. Non thermal irreversible electroporation (IRE) is inducing apoptotic cell death, is tissue-specific and effective. The comparison between AC/DC energy sources has not been systematically approached, clinically relevant parameters are yet to be validated. Methods: 12 farm pigs (female, 6m old, 45-55kg) underwent thoracotomy and epicardial IRE shock delivery. Square DC/AC pulse generators were connected to planar stainless-steel electrode (6x6mm) in a suction cup for tissue adherence, versus reference patch on the animal back (ca. 40cm from heart). High voltage AC/DC pulses (10 and 2 animals, 100 µs, 60 pulses, each set of 400, 600 and 800 V) were delivered in myorelaxation, at target frequency 80/min. in 3x3 grid application on left ventricle and 2*2 grid on left atrium, marked by sur
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
—
OECD FORD obor
30201 - Cardiac and Cardiovascular systems
Návaznosti výsledku
Projekt
<a href="/cs/project/LO1210" target="_blank" >LO1210: Energie v podmínkách udržitelného rozvoje (EN-PUR)</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů