Advanced Pharmacokinetic Modeling in Small-Animal Compressed-Sensing DCE-MRI

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F19%3APU132776" target="_blank" >RIV/00216305:26220/19:PU132776 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Advanced Pharmacokinetic Modeling in Small-Animal Compressed-Sensing DCE-MRI

Popis výsledku v původním jazyce

To overcome the physical limits of the achievable spatial and temporal resolution in Dynamic Contrast-Enhanced (DCE) MRI, compressed-sensing (CS) techniques have been proposed [1]. So far, CS has been combined only with simpler pharmacokinetic (PK) models (e.g. generalized kinetic model [2]), which do not provide estimates of blood flow, Fb, and permeability-surface area product, PS. To the authors' knowledge, no CS DCE has been shown for advanced PK models, i.e. models providing also estimates of Fb and PS. This is probably because the requirements of these models on temporal resolution and the signal-to- noise ratio (SNR) are much higher than for simple PK models. We use an advanced PK model (adiabatic approximation of the tissue homogeneity model - ATH) in combination with CS, based on a 3D radial golden-angle (GA) stack-of-stars (SOS) acquisition [3] and the L+S reconstruction [4].

Název v anglickém jazyce

Advanced Pharmacokinetic Modeling in Small-Animal Compressed-Sensing DCE-MRI

Popis výsledku anglicky

To overcome the physical limits of the achievable spatial and temporal resolution in Dynamic Contrast-Enhanced (DCE) MRI, compressed-sensing (CS) techniques have been proposed [1]. So far, CS has been combined only with simpler pharmacokinetic (PK) models (e.g. generalized kinetic model [2]), which do not provide estimates of blood flow, Fb, and permeability-surface area product, PS. To the authors' knowledge, no CS DCE has been shown for advanced PK models, i.e. models providing also estimates of Fb and PS. This is probably because the requirements of these models on temporal resolution and the signal-to- noise ratio (SNR) are much higher than for simple PK models. We use an advanced PK model (adiabatic approximation of the tissue homogeneity model - ATH) in combination with CS, based on a 3D radial golden-angle (GA) stack-of-stars (SOS) acquisition [3] and the L+S reconstruction [4].

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20601 - Medical engineering

Projekt

<a href="/cs/project/GA16-13830S" target="_blank" >GA16-13830S: Perfuzní zobrazování v magnetické rezonanci pomocí komprimovaného snímání</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů