Circadian Rhythms of Human Brain - Electrical Impedance

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F21%3APU142131" target="_blank" >RIV/00216305:26220/21:PU142131 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Circadian Rhythms of Human Brain - Electrical Impedance

Popis výsledku v původním jazyce

Rationale: Long-term data collection using implantable neural sense and stimulation (INSS) devices in patients with epilepsy enables investigation of ultradian, circadian and infradian rhythms in sleep, seizures, interictal epileptiform discharges (IED), and brain impedance. It has long been recognized that IED and seizures have circadian patterns. Recent studies also highlight the importance of circadian changes in brain extracellular space, and the functional role of slow-wave sleep and the associated increase in extracellular space volume that is hypothesized to provide improved metabolite and protein clearance. The direct evidence for increased extracellular space volume during sleep primarily comes from rodent studies, and a few human imaging studies with limited temporal sampling. Here we investigate a potential surrogate of extracellular volume, the brain electrical impedance in hippocampus (HPC) and anterior nucleus of thalamus (ANT) over multiple months in four ambulatory humans with drug res

Název v anglickém jazyce

Circadian Rhythms of Human Brain - Electrical Impedance

Popis výsledku anglicky

Rationale: Long-term data collection using implantable neural sense and stimulation (INSS) devices in patients with epilepsy enables investigation of ultradian, circadian and infradian rhythms in sleep, seizures, interictal epileptiform discharges (IED), and brain impedance. It has long been recognized that IED and seizures have circadian patterns. Recent studies also highlight the importance of circadian changes in brain extracellular space, and the functional role of slow-wave sleep and the associated increase in extracellular space volume that is hypothesized to provide improved metabolite and protein clearance. The direct evidence for increased extracellular space volume during sleep primarily comes from rodent studies, and a few human imaging studies with limited temporal sampling. Here we investigate a potential surrogate of extracellular volume, the brain electrical impedance in hippocampus (HPC) and anterior nucleus of thalamus (ANT) over multiple months in four ambulatory humans with drug res

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů