Network Excitability in Human Mesial Temporal Lobe Epilepsy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F21%3APU142129" target="_blank" >RIV/00216305:26220/21:PU142129 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Network Excitability in Human Mesial Temporal Lobe Epilepsy

Popis výsledku v původním jazyce

Objective: Seizures are a consequence of abnormal brain network excitability. Two fundamental electrophysiologic biomarkers of epilepsy and network excitability, interictal epileptiform spikes (IES) and seizures, show circadian patterns supporting behavioral state modulation of brain excitability. The circadian patterns of seizures and IES in mesial temporal lobe epilepsy (mTLE), however, differ as seizures show daytime peaks and IES show nocturnal peaks in occurrence. Methods: We investigated this paradox in mTLE brain excitability using a chronically implanted device enabling continuous intracranial EEG (iEEG), wireless data streaming, and electrical stimulation in four patients with electrodes targeting two key mTLE network nodes, the hippocampus (Hc) and anterior nucleus of the thalamus (ANT). Automated sleep staging, IES rates, and seizure detection iEEG classifiers provided dense behavioral state and brain excitability tracking. The Hc evoked responses to continuous ANT electrical stimulation w

Název v anglickém jazyce

Network Excitability in Human Mesial Temporal Lobe Epilepsy

Popis výsledku anglicky

Objective: Seizures are a consequence of abnormal brain network excitability. Two fundamental electrophysiologic biomarkers of epilepsy and network excitability, interictal epileptiform spikes (IES) and seizures, show circadian patterns supporting behavioral state modulation of brain excitability. The circadian patterns of seizures and IES in mesial temporal lobe epilepsy (mTLE), however, differ as seizures show daytime peaks and IES show nocturnal peaks in occurrence. Methods: We investigated this paradox in mTLE brain excitability using a chronically implanted device enabling continuous intracranial EEG (iEEG), wireless data streaming, and electrical stimulation in four patients with electrodes targeting two key mTLE network nodes, the hippocampus (Hc) and anterior nucleus of the thalamus (ANT). Automated sleep staging, IES rates, and seizure detection iEEG classifiers provided dense behavioral state and brain excitability tracking. The Hc evoked responses to continuous ANT electrical stimulation w

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů