Deep Brain Stimulation of Anterior Nuclei of the Thalamus and Hippocampal Seizure Rate Modulate Verbal Memory Performance

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F22%3A00360017" target="_blank" >RIV/68407700:21460/22:00360017 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21730/22:00360017

Výsledek na webu

<a href="https://doi.org/10.1109/eIT53891.2022.9813930" target="_blank" >https://doi.org/10.1109/eIT53891.2022.9813930</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1109/eIT53891.2022.9813930" target="_blank" >10.1109/eIT53891.2022.9813930</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Deep Brain Stimulation of Anterior Nuclei of the Thalamus and Hippocampal Seizure Rate Modulate Verbal Memory Performance

Popis výsledku v původním jazyce

Verbal memory impairment is a common symptom of temporal lobe epilepsy (TLE). The ability to encode and recall verbal memories can be probed with the classic free recall task. We hypothesized that increased seizure frequency will lead to decreased verbal memory. We investigated this hypothesis in patients receiving chronic stimulation to bilateral anterior nuclei of the thalamus (ANT) deep brain stimulation (DBS). Recordings were obtained from individuals with drug resistant mesial TLE implanted with an investigational Medtronic Summit RC+S,Ñ¢ sensing and stimulation device. As patient seizure diaries are notoriously inaccurate, the patient,Äôs intracranial electroencephalography (iEEG) was scored for seizures using a validated seizure classifier with trained epileptologist review, resulting in a reliable seizure diary. The subjects completed free recall memory tasks in their home environment with iEEG and behavioral data streamed to a handheld device and cloud repository. Using multivariate analysis of variance, we were able to determine that ANT stimulation modulates memory performance. Further, changes in the seizure rate were predictive of changes in memory performance as captured by a generalized linear model (GLM). Emerging devices for electrical stimulation of the brain enabling continuous streaming of the iEEG data are crucial for long-term studies of underlying brain dynamics during cognitive tasks. However, not all patients are candidates for devices with chronic sensing capabilities, and this study suggests that changes in verbal memory performance may provide a suitable metric of therapy effectiveness in lieu of a reliable, objective seizure diary.

Název v anglickém jazyce

Deep Brain Stimulation of Anterior Nuclei of the Thalamus and Hippocampal Seizure Rate Modulate Verbal Memory Performance

Popis výsledku anglicky

Verbal memory impairment is a common symptom of temporal lobe epilepsy (TLE). The ability to encode and recall verbal memories can be probed with the classic free recall task. We hypothesized that increased seizure frequency will lead to decreased verbal memory. We investigated this hypothesis in patients receiving chronic stimulation to bilateral anterior nuclei of the thalamus (ANT) deep brain stimulation (DBS). Recordings were obtained from individuals with drug resistant mesial TLE implanted with an investigational Medtronic Summit RC+S,Ñ¢ sensing and stimulation device. As patient seizure diaries are notoriously inaccurate, the patient,Äôs intracranial electroencephalography (iEEG) was scored for seizures using a validated seizure classifier with trained epileptologist review, resulting in a reliable seizure diary. The subjects completed free recall memory tasks in their home environment with iEEG and behavioral data streamed to a handheld device and cloud repository. Using multivariate analysis of variance, we were able to determine that ANT stimulation modulates memory performance. Further, changes in the seizure rate were predictive of changes in memory performance as captured by a generalized linear model (GLM). Emerging devices for electrical stimulation of the brain enabling continuous streaming of the iEEG data are crucial for long-term studies of underlying brain dynamics during cognitive tasks. However, not all patients are candidates for devices with chronic sensing capabilities, and this study suggests that changes in verbal memory performance may provide a suitable metric of therapy effectiveness in lieu of a reliable, objective seizure diary.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

20201 - Electrical and electronic engineering

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

IEEE International Conference on Electro-Information Technology

ISBN

978-1-6654-8010-9

ISSN

2154-0357

e-ISSN

2154-0373

Počet stran výsledku

4

Strana od-do

114-117

Název nakladatele

IEEE (Institute of Electrical and Electronics Engineers)

Místo vydání

—

Místo konání akce

Minnesota State University, Mankato

Datum konání akce

19. 5. 2022

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

—