Effects of the administration of different buffered balanced crystalloid solutions on acid-base and electrolyte status in dogs with gastric dilation-volvulus syndrome: a randomized clinical trial

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F22%3APU142400" target="_blank" >RIV/00216305:26220/22:PU142400 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16170/21:43879214

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1938973621001033" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1938973621001033</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tcam.2021.100613" target="_blank" >10.1016/j.tcam.2021.100613</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of the administration of different buffered balanced crystalloid solutions on acid-base and electrolyte status in dogs with gastric dilation-volvulus syndrome: a randomized clinical trial

Popis výsledku v původním jazyce

Objective: To investigate the effect of three different buffered balanced crystalloid solutions on acid–base status and electrolyte concentrations in dogs with gastric dilation–volvulus (GDV) syndrome. Methods: The study design was a prospective, randomized clinical trial of 40 dogs. The dogs were randomly assigned to one of three groups according to the fluid used: Hartmann’s solution (H), Plasmalyte (PL), and Ringerfundin (RF). Hemoglobin, albumin, lactate, electrolyte, and acid–base parameters were determined before fluid administration (T0) and at the end of surgery (T1). Results were assessed by one-way ANOVA, Fisher’s exact test, the Wilcoxon signed-rank test, the Kruskal–Wallis test, and a linear mixed-effect regression model. A significance level of 0.05 was used in all analyses. Results: Bicarbonate and base excess (BE) levels increased and chloride concentration decreased in the PL group; in contrast, strong ion difference apparent (SIDapp) decreased and chloride concentration increased in the RF group. The mixed-effect model confirmed a significant interaction between the type of solution and time on the changes in bicarbonate, BE, anion gap (AG), SIDapp, and chloride levels. Clinical significance: Significantly different effects in acid–base parameters were observed in dogs after intravenous administration of H, PL, and RF. However, clinical significance of these changes is lacking, requiring further investigation in a larger randomized controlled clinical trial.

Název v anglickém jazyce

Effects of the administration of different buffered balanced crystalloid solutions on acid-base and electrolyte status in dogs with gastric dilation-volvulus syndrome: a randomized clinical trial

Popis výsledku anglicky

Objective: To investigate the effect of three different buffered balanced crystalloid solutions on acid–base status and electrolyte concentrations in dogs with gastric dilation–volvulus (GDV) syndrome. Methods: The study design was a prospective, randomized clinical trial of 40 dogs. The dogs were randomly assigned to one of three groups according to the fluid used: Hartmann’s solution (H), Plasmalyte (PL), and Ringerfundin (RF). Hemoglobin, albumin, lactate, electrolyte, and acid–base parameters were determined before fluid administration (T0) and at the end of surgery (T1). Results were assessed by one-way ANOVA, Fisher’s exact test, the Wilcoxon signed-rank test, the Kruskal–Wallis test, and a linear mixed-effect regression model. A significance level of 0.05 was used in all analyses. Results: Bicarbonate and base excess (BE) levels increased and chloride concentration decreased in the PL group; in contrast, strong ion difference apparent (SIDapp) decreased and chloride concentration increased in the RF group. The mixed-effect model confirmed a significant interaction between the type of solution and time on the changes in bicarbonate, BE, anion gap (AG), SIDapp, and chloride levels. Clinical significance: Significantly different effects in acid–base parameters were observed in dogs after intravenous administration of H, PL, and RF. However, clinical significance of these changes is lacking, requiring further investigation in a larger randomized controlled clinical trial.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40301 - Veterinary science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

TOP COMPANION ANIM M

ISSN

1938-9736

e-ISSN

1946-9837

Svazek periodika

46

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

1-10

Kód UT WoS článku

000740309000014

EID výsledku v databázi Scopus

2-s2.0-85121133281