Acid-base, electrolyte and lactate abnormalities as well as gastric necrosis and survival in dogs with gastric dilation-volvulus syndrome. A retrospective study in 75 dogs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F20%3A43878430" target="_blank" >RIV/62157124:16170/20:43878430 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1938973620300015" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1938973620300015</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tcam.2020.100403" target="_blank" >10.1016/j.tcam.2020.100403</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Acid-base, electrolyte and lactate abnormalities as well as gastric necrosis and survival in dogs with gastric dilation-volvulus syndrome. A retrospective study in 75 dogs

Popis výsledku v původním jazyce

Gastric dilation-volvulus (GDV) syndrome in dogs is associated with complex metabolic, acid-base, and elec-trolyte abnormalities. The aim of this study was to evaluate previously analyzed factors (lactate and BE) incombination with other acid-base parameters (pH, pCO2, bicarbonate, base excess [BE], anion gap [AG], andstrong ion difference) and electrolyte concentrations and to evaluate their association with the incidence ofgastric necrosis and outcome in dogs with GDV. A retrospective study in 75 dogs with gastric dilation-volvu-lus syndrome, University veterinary teaching hospital. Medical records were reviewed including signalment,history, initial plasma lactate, acid-base parameters, and electrolyte concentrations, surgicalfindings andoutcome. The overall mortality was 18.7%. In dogs with gastric necrosis, higher initial plasma lactate (median5.84 vs. 3.36 mmol/L) and AG (20.7 vs. 16.55 mmol/L) and lower pH (7.29 vs. 7.36), bicarbonate (18.7 vs. 22.9mmol/L), and BE concentration (8.1 vs.1.85 mmol/L) were found compared to dogs without gastric necro-sis. Anorganic phosphorus was the only electrolyte investigated for which a significant difference was notedbetween dogs with and without gastric necrosis (1.93 vs. 1.39 mmol/L). The initial plasma lactate concentra-tion (3.36 mmol/L vs. 9.68 mmol/L) and AG (16.8 vs. 20.95 mmol/L) were lower in survivors than nonsurvi-vors. Survivors had higher pH (7.35 vs. 7.27), bicarbonate concentrations (22.9 vs. 17.35 mmol/L), and BE(1.9 vs.9.55 mmol/L) compared to nonsurvivors. Anorganic phosphorus was ultimately the only electro-lyte with a significant difference between survivors and nonsurvivors (1.4 vs. 1.84 mmol/L). A multivariatelogistic regression model of combination lactate, pH, bicarbonate, BE, AG, and anorganic phosphorus identi-fied pH7.331 and bicarbonate as factors independently associated with gastric necrosis. Similarly, pH?7.331, bicarbonate and anorganic phosphorus were independently associated with outcome. Higher initialplasma lactate, AG and anorganic phosphorus levels, and lower pH, BE and bicarbonate concentrations werefound in GDV dogs with gastric necrosis. Similarly, initially higher plasma lactate, AG and anorganicphosphorus concentrations, and lower pH, BE and bicarbonate were found in GDV dogs who requiredeuthanasia or who died after surgery. Of these parameters, pH and bicarbonate were strongly andindependently associated with gastric necrosis, and pH, bicarbonate and phosphorus were indepen-dently associated with outcome.

Název v anglickém jazyce

Acid-base, electrolyte and lactate abnormalities as well as gastric necrosis and survival in dogs with gastric dilation-volvulus syndrome. A retrospective study in 75 dogs

Popis výsledku anglicky

Gastric dilation-volvulus (GDV) syndrome in dogs is associated with complex metabolic, acid-base, and elec-trolyte abnormalities. The aim of this study was to evaluate previously analyzed factors (lactate and BE) incombination with other acid-base parameters (pH, pCO2, bicarbonate, base excess [BE], anion gap [AG], andstrong ion difference) and electrolyte concentrations and to evaluate their association with the incidence ofgastric necrosis and outcome in dogs with GDV. A retrospective study in 75 dogs with gastric dilation-volvu-lus syndrome, University veterinary teaching hospital. Medical records were reviewed including signalment,history, initial plasma lactate, acid-base parameters, and electrolyte concentrations, surgicalfindings andoutcome. The overall mortality was 18.7%. In dogs with gastric necrosis, higher initial plasma lactate (median5.84 vs. 3.36 mmol/L) and AG (20.7 vs. 16.55 mmol/L) and lower pH (7.29 vs. 7.36), bicarbonate (18.7 vs. 22.9mmol/L), and BE concentration (8.1 vs.1.85 mmol/L) were found compared to dogs without gastric necro-sis. Anorganic phosphorus was the only electrolyte investigated for which a significant difference was notedbetween dogs with and without gastric necrosis (1.93 vs. 1.39 mmol/L). The initial plasma lactate concentra-tion (3.36 mmol/L vs. 9.68 mmol/L) and AG (16.8 vs. 20.95 mmol/L) were lower in survivors than nonsurvi-vors. Survivors had higher pH (7.35 vs. 7.27), bicarbonate concentrations (22.9 vs. 17.35 mmol/L), and BE(1.9 vs.9.55 mmol/L) compared to nonsurvivors. Anorganic phosphorus was ultimately the only electro-lyte with a significant difference between survivors and nonsurvivors (1.4 vs. 1.84 mmol/L). A multivariatelogistic regression model of combination lactate, pH, bicarbonate, BE, AG, and anorganic phosphorus identi-fied pH7.331 and bicarbonate as factors independently associated with gastric necrosis. Similarly, pH?7.331, bicarbonate and anorganic phosphorus were independently associated with outcome. Higher initialplasma lactate, AG and anorganic phosphorus levels, and lower pH, BE and bicarbonate concentrations werefound in GDV dogs with gastric necrosis. Similarly, initially higher plasma lactate, AG and anorganicphosphorus concentrations, and lower pH, BE and bicarbonate were found in GDV dogs who requiredeuthanasia or who died after surgery. Of these parameters, pH and bicarbonate were strongly andindependently associated with gastric necrosis, and pH, bicarbonate and phosphorus were indepen-dently associated with outcome.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40301 - Veterinary science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Topics in Companion Animal Medicine

ISSN

1938-9736

e-ISSN

—

Svazek periodika

39

Číslo periodika v rámci svazku

JUN

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

—

Kód UT WoS článku

000537708900002

EID výsledku v databázi Scopus

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