Diagnostic value of HMGB1 for detection of gastric necrosis in dogs with gastric dilatation-volvulus syndrome.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F13%3A43872490" target="_blank" >RIV/62157124:16170/13:43872490 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Diagnostic value of HMGB1 for detection of gastric necrosis in dogs with gastric dilatation-volvulus syndrome.

Popis výsledku v původním jazyce

Background: High mobility group box 1 (HMGB1) is a nuclear protein which is released from cells during cell necrosis or actively as a late cytokine. Gastric necrosis is one of the major complication and negative prognostic factor in dogs with gastric dilatation-volvulus syndrome (GDV). Objective: The aim of this study was to determinate diagnostic value of HMGB1 for detection of gastric necrosis in dogs with GDV. Methods: Fifty-four dogs with GDV were enrolled in this prospective study. Blood was collected before surgery from jugular vein and HMGB1 was detected using ELISA method (HMGB1, IBL International GmbH, Germany) from serum. Results: Sixteen dogs had macroscopically evident gastric necrosis and underwent partial gastrectomy or euthanasia. Thirty-eight dogs did not have gastric necrosis and were discharged from the hospital after successful treatment. Dogs with gastric necrosis had significantly higher HMGB1 levels (median 9.4 ng/ml, min-max 1.1-36.1 ng/ml) in comparison to those

Název v anglickém jazyce

Diagnostic value of HMGB1 for detection of gastric necrosis in dogs with gastric dilatation-volvulus syndrome.

Popis výsledku anglicky

Background: High mobility group box 1 (HMGB1) is a nuclear protein which is released from cells during cell necrosis or actively as a late cytokine. Gastric necrosis is one of the major complication and negative prognostic factor in dogs with gastric dilatation-volvulus syndrome (GDV). Objective: The aim of this study was to determinate diagnostic value of HMGB1 for detection of gastric necrosis in dogs with GDV. Methods: Fifty-four dogs with GDV were enrolled in this prospective study. Blood was collected before surgery from jugular vein and HMGB1 was detected using ELISA method (HMGB1, IBL International GmbH, Germany) from serum. Results: Sixteen dogs had macroscopically evident gastric necrosis and underwent partial gastrectomy or euthanasia. Thirty-eight dogs did not have gastric necrosis and were discharged from the hospital after successful treatment. Dogs with gastric necrosis had significantly higher HMGB1 levels (median 9.4 ng/ml, min-max 1.1-36.1 ng/ml) in comparison to those

Druh

O - Ostatní výsledky

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů