Determination of ionic concentration in microfluidics using electrical methods

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F26%3A0197953" target="_blank" >RIV/00216305:26220/26:0197953 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62156489:43210/25:43927042

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0165993624005983?via=ihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0165993624005983?via=ihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.sna.2025.116719" target="_blank" >10.1016/j.sna.2025.116719</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Determination of ionic concentration in microfluidics using electrical methods

Popis výsledku v původním jazyce

Microfluidic systems are essential in various scientific and engineering applications, especially in biochemical analysis, medical diagnostics, and pharmaceutical research. Accurate monitoring and control of ionic concentration within these systems are essential for achieving high efficiency and specificity in their applications. This study investigates using van der Pauw (vdP) structures and 4-probe line methods, adapted from semiconductor technology, to measure ionic concentrations in microfluidic channels. These methods offer precise, real-time monitoring without requiring additional fabrication steps or specialized electrode materials. We fabricated microfluidic chips with dual deep reactive ion etching and anodic bonding. These chips, integrated into an automated system, were tested for KCl concentrations (0.1–4 M) across various channel depths (9.55 ± 0.23) µm, (22.37 ± 0.41) µm, and (82.26 ± 1.56) µm. Electrical measurements showed the vdP method provides higher accuracy and lower standard deviation than the 4-probe line method. Our findings demonstrate the potential for integrating vdP structures into complex microfluidic systems for precise, real-time monitoring of ionic concentrations, enhancing the functionality and reliability of microfluidic devices.

Název v anglickém jazyce

Determination of ionic concentration in microfluidics using electrical methods

Popis výsledku anglicky

Microfluidic systems are essential in various scientific and engineering applications, especially in biochemical analysis, medical diagnostics, and pharmaceutical research. Accurate monitoring and control of ionic concentration within these systems are essential for achieving high efficiency and specificity in their applications. This study investigates using van der Pauw (vdP) structures and 4-probe line methods, adapted from semiconductor technology, to measure ionic concentrations in microfluidic channels. These methods offer precise, real-time monitoring without requiring additional fabrication steps or specialized electrode materials. We fabricated microfluidic chips with dual deep reactive ion etching and anodic bonding. These chips, integrated into an automated system, were tested for KCl concentrations (0.1–4 M) across various channel depths (9.55 ± 0.23) µm, (22.37 ± 0.41) µm, and (82.26 ± 1.56) µm. Electrical measurements showed the vdP method provides higher accuracy and lower standard deviation than the 4-probe line method. Our findings demonstrate the potential for integrating vdP structures into complex microfluidic systems for precise, real-time monitoring of ionic concentrations, enhancing the functionality and reliability of microfluidic devices.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

<a href="/cs/project/EF16_025%2F0007314" target="_blank" >EF16_025/0007314: Multioborový výzkum pro zvýšení aplikačního potenciálu nanomateriálů v zemědělské praxi</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

SENSORS AND ACTUATORS A-PHYSICAL

ISSN

0924-4247

e-ISSN

1873-3069

Svazek periodika

392

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

6

Strana od-do

1-6

Kód UT WoS článku

001502696100003

EID výsledku v databázi Scopus

2-s2.0-105006819633