Chiral Analysis of Drug Residuals in Wastewaters

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F11%3APU93670" target="_blank" >RIV/00216305:26310/11:PU93670 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Chiral Analysis of Drug Residuals in Wastewaters

Popis výsledku v původním jazyce

Many of the pharmacologically active substances present in the environment are chiral. However, there is only little data concerning their fate in the environment on the enantiomeric level. Chiral pharmaceuticals are known to exhibit stereoselective behaviour when situated in biological system such as human body. Therefore, stereoselective behaviour of chiral drugs is very likely to happen in the environment. Enantioselective HPLC-DAD method using Chiralpak AD as a chiral column was developed for the analysis of two non-steroidal anti-inflammatory drugs ibuprofen and ketoprofen in wastewater samples. Before the chiral analysis was applied, the sum of enantiomers was quantified by HPLC-ESI-MS. After this, the samples were analyzed by chiral HPLC using diode array detector. It was found out that the diode array detector is not sensitive and selective enough for the chiral analysis of wastewater samples. Drugs are generally present in the wastewater in very small amounts and when they are

Název v anglickém jazyce

Chiral Analysis of Drug Residuals in Wastewaters

Popis výsledku anglicky

Many of the pharmacologically active substances present in the environment are chiral. However, there is only little data concerning their fate in the environment on the enantiomeric level. Chiral pharmaceuticals are known to exhibit stereoselective behaviour when situated in biological system such as human body. Therefore, stereoselective behaviour of chiral drugs is very likely to happen in the environment. Enantioselective HPLC-DAD method using Chiralpak AD as a chiral column was developed for the analysis of two non-steroidal anti-inflammatory drugs ibuprofen and ketoprofen in wastewater samples. Before the chiral analysis was applied, the sum of enantiomers was quantified by HPLC-ESI-MS. After this, the samples were analyzed by chiral HPLC using diode array detector. It was found out that the diode array detector is not sensitive and selective enough for the chiral analysis of wastewater samples. Drugs are generally present in the wastewater in very small amounts and when they are

Druh

O - Ostatní výsledky

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů