A new approach to characterization of ultrasound contrast agents

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F15%3APU115324" target="_blank" >RIV/00216305:26310/15:PU115324 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A new approach to characterization of ultrasound contrast agents

Popis výsledku v původním jazyce

Microbubbles are used as contrast agents in combination with ultrasound and currently are proposed for drug delivery applications. For this development is necessary to identify a microbubble formation process and stability of the system. In this respectnew physico-chemical approach to characterization of SonoVue? microbubbles and phospholipid systems was found. Basic properties of these systems such as size distribution, zeta potential and phase stability of particles or solubilization ability were studied using spectroscopic methods because of behavior in biological system. Selected solutes, which could serve as a model substances at the use of these systems for theranostic applications were investigated. Other phospholipids and surfactants were compared with SonoVue? for evaluation of effect of system composition on final properties of the system. It was found that surface properties of phospholipid systems are significant for microbubble formation and stability of contrast agents.

Název v anglickém jazyce

A new approach to characterization of ultrasound contrast agents

Popis výsledku anglicky

Microbubbles are used as contrast agents in combination with ultrasound and currently are proposed for drug delivery applications. For this development is necessary to identify a microbubble formation process and stability of the system. In this respectnew physico-chemical approach to characterization of SonoVue? microbubbles and phospholipid systems was found. Basic properties of these systems such as size distribution, zeta potential and phase stability of particles or solubilization ability were studied using spectroscopic methods because of behavior in biological system. Selected solutes, which could serve as a model substances at the use of these systems for theranostic applications were investigated. Other phospholipids and surfactants were compared with SonoVue? for evaluation of effect of system composition on final properties of the system. It was found that surface properties of phospholipid systems are significant for microbubble formation and stability of contrast agents.

Druh

O - Ostatní výsledky

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/LO1211" target="_blank" >LO1211: Centrum materiálového výzkumu na FCH VUT v Brně - udržitelnost a rozvoj</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů