Optimization of derivatization of acidic drugs for analysis by GC-MS and its application for determination of drug residues in wastewater

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F15%3APU116561" target="_blank" >RIV/00216305:26310/15:PU116561 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Optimization of derivatization of acidic drugs for analysis by GC-MS and its application for determination of drug residues in wastewater

Popis výsledku v původním jazyce

This article is focused on optimization of derivatization of acidic drugs from the group of non-steroidal anti-inflammatory drugs (NSAID): salicylic acid, ibuprofen, naproxen, ketoprofen and diclofenac. Derivatization is a necessary step for analysis of pharmaceuticals by GC. MSTFA (N-methylN-(trimethylsilyl)trifluoroacetamide) and BSTFA (N,Obis(trimethylsilyl)trifluoroacetamide) were used as a derivatization reagents and tested under different conditions: volume, temperature and time of derivatization. Results of optimization were compared and optimized conditions were successfully applied for analysis of real samples of wastewater. Wastewater samples were collected from influent and effluent of wastewater treatment plant (WWTP). The whole analytical procedure involved solid phase extraction (SPE), optimized derivatization and analysis by GC-TOF MS. Limits of detection (LOD) ranged between 8.9 - 71.6 ng.L-1 and limits of quantification (LOQ) ranged between 29.5 – 238.7 ng.L-1 depending on the specific compound. Concentration of selected drugs in real samples of wastewater varied from 0.1 to 30 g.L-1 in influent and from 0.05 to 2 g.L-1 in effluent, depending on the compound.

Název v anglickém jazyce

Optimization of derivatization of acidic drugs for analysis by GC-MS and its application for determination of drug residues in wastewater

Popis výsledku anglicky

This article is focused on optimization of derivatization of acidic drugs from the group of non-steroidal anti-inflammatory drugs (NSAID): salicylic acid, ibuprofen, naproxen, ketoprofen and diclofenac. Derivatization is a necessary step for analysis of pharmaceuticals by GC. MSTFA (N-methylN-(trimethylsilyl)trifluoroacetamide) and BSTFA (N,Obis(trimethylsilyl)trifluoroacetamide) were used as a derivatization reagents and tested under different conditions: volume, temperature and time of derivatization. Results of optimization were compared and optimized conditions were successfully applied for analysis of real samples of wastewater. Wastewater samples were collected from influent and effluent of wastewater treatment plant (WWTP). The whole analytical procedure involved solid phase extraction (SPE), optimized derivatization and analysis by GC-TOF MS. Limits of detection (LOD) ranged between 8.9 - 71.6 ng.L-1 and limits of quantification (LOQ) ranged between 29.5 – 238.7 ng.L-1 depending on the specific compound. Concentration of selected drugs in real samples of wastewater varied from 0.1 to 30 g.L-1 in influent and from 0.05 to 2 g.L-1 in effluent, depending on the compound.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10500 - Earth and related environmental sciences

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Fresenius Environmental Bulletin

ISSN

1018-4619

e-ISSN

1610-2304

Svazek periodika

24

Číslo periodika v rámci svazku

11a

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

9

Strana od-do

3813-3821

Kód UT WoS článku

000367698500014

EID výsledku v databázi Scopus

2-s2.0-84958179344