Study of the glass transition of co-amorphous drug by DMA

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Study of the glass transition of co-amorphous drug by DMA

Popis výsledku v původním jazyce

Nowadays in pharmaceutical research is problem that new chemical entities are poorly water soluble and therefore present a low dissolution rate. One approach to increase their solubility is to convert the crystalline form of a drug into the amorphous form. In this study, the co-amorphous IND-TRY mixtures were prepared by mechanical activation – ball milling. It was given different amount of polyvinylpyrrolidon to the mixture and was characterized. Solid - state properties were analyzed by dynamic mechanical analysis (DMA). It was found that addition of polyvinylpyrrolidon improved stability compared to the pure co-amorphous form. Glass transition state is growing with addition of PVP.

Název v anglickém jazyce

Study of the glass transition of co-amorphous drug by DMA

Popis výsledku anglicky

Nowadays in pharmaceutical research is problem that new chemical entities are poorly water soluble and therefore present a low dissolution rate. One approach to increase their solubility is to convert the crystalline form of a drug into the amorphous form. In this study, the co-amorphous IND-TRY mixtures were prepared by mechanical activation – ball milling. It was given different amount of polyvinylpyrrolidon to the mixture and was characterized. Solid - state properties were analyzed by dynamic mechanical analysis (DMA). It was found that addition of polyvinylpyrrolidon improved stability compared to the pure co-amorphous form. Glass transition state is growing with addition of PVP.

Druh

D - Stať ve sborníku

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

XVI. Workshop of physical chemists and electrochemists Book of abstracts

ISBN

978-80-210-8267-0

ISSN

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e-ISSN

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Počet stran výsledku

3

Strana od-do

212-214

Název nakladatele

MUNI press

Místo vydání

Masaryk University, Brno, Czech Republic

Místo konání akce

Brno

Datum konání akce

6. 6. 2016

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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