Improving dissolution rate of poorly soluble drugs by milling and co-milling technique

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F21%3A43922745" target="_blank" >RIV/60461373:22310/21:43922745 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.icct.cz/cs/Amca-ICCT/media/content/2021/proceedings/ICCT2021-Proceedings.pdf" target="_blank" >https://www.icct.cz/cs/Amca-ICCT/media/content/2021/proceedings/ICCT2021-Proceedings.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Improving dissolution rate of poorly soluble drugs by milling and co-milling technique

Popis výsledku v původním jazyce

Milling of APIs alone or co-milling of APIs with an excipient are used as one of the efficient techniques that improve physicochemical properties such as solubility and dissolution rate. The enhancement of solubility may be caused by the drug amorphization. Each drug has a different ability to form an amorphous phase (glass forming ability). The influence of excipients is also crucial because the proper choice thereof increases the dissolution rates of API. The aim of this work was to compare the dissolution behavior of drugs having different glass forming ability. Furthermore, the effect of the mixture preparation method was compared in terms of dissolution properties. Our results indicate that co-milling is a valuable approach in enhancing the dissolution rates of poorly water-soluble APIs. Co-milling results in a much faster release of the API, than its milling itself and subsequent mixing with the excipient.

Název v anglickém jazyce

Improving dissolution rate of poorly soluble drugs by milling and co-milling technique

Popis výsledku anglicky

Milling of APIs alone or co-milling of APIs with an excipient are used as one of the efficient techniques that improve physicochemical properties such as solubility and dissolution rate. The enhancement of solubility may be caused by the drug amorphization. Each drug has a different ability to form an amorphous phase (glass forming ability). The influence of excipients is also crucial because the proper choice thereof increases the dissolution rates of API. The aim of this work was to compare the dissolution behavior of drugs having different glass forming ability. Furthermore, the effect of the mixture preparation method was compared in terms of dissolution properties. Our results indicate that co-milling is a valuable approach in enhancing the dissolution rates of poorly water-soluble APIs. Co-milling results in a much faster release of the API, than its milling itself and subsequent mixing with the excipient.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 8th International Conference on Chemical Technology

ISBN

978-80-88307-08-2

ISSN

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e-ISSN

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Počet stran výsledku

5

Strana od-do

220-224

Název nakladatele

Czech Society of Industrial Chemistry

Místo vydání

Prague

Místo konání akce

Praha

Datum konání akce

3. 5. 2021

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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