The effect of pH and multivalent ions on the mechanical properties of gels with micellar nanodomains

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F18%3APU131470" target="_blank" >RIV/00216305:26310/18:PU131470 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The effect of pH and multivalent ions on the mechanical properties of gels with micellar nanodomains

Popis výsledku v původním jazyce

The aim of this study was to examine the properties and behaviour of phase-separated hydrogels. These can be prepared by interaction of specific biopolymer (sodium hyaluronate – Hya) with oppositely charged surfactant (carbethopendecinium bromide – Septonex). Using the method of rheology, the effect of pH and addition of multivalent ions to the mixture of Hya-Septonex, was studied. Samples underwent both oscillatory and flow measurements. Generally, pH suppressed the elasticity of Hya-Septonex hydrogels by decreasing both the elastic and viscous moduli in comparison to standard pH-uncontrolled samples. Molecular weight of polymer has also direct influence in presence of pH influence. Higher molecular weight of hyaluronan caused the elastic modulus to be higher than viscous even in case of lower pH. However, using the pH around or below the pKa of Hya (pH=3.5) caused that the most of the COO- groups of Hya were not dissociated, thus the gels were not formed. On the other hand, higher pH (pH=9) resulted

Název v anglickém jazyce

The effect of pH and multivalent ions on the mechanical properties of gels with micellar nanodomains

Popis výsledku anglicky

The aim of this study was to examine the properties and behaviour of phase-separated hydrogels. These can be prepared by interaction of specific biopolymer (sodium hyaluronate – Hya) with oppositely charged surfactant (carbethopendecinium bromide – Septonex). Using the method of rheology, the effect of pH and addition of multivalent ions to the mixture of Hya-Septonex, was studied. Samples underwent both oscillatory and flow measurements. Generally, pH suppressed the elasticity of Hya-Septonex hydrogels by decreasing both the elastic and viscous moduli in comparison to standard pH-uncontrolled samples. Molecular weight of polymer has also direct influence in presence of pH influence. Higher molecular weight of hyaluronan caused the elastic modulus to be higher than viscous even in case of lower pH. However, using the pH around or below the pKa of Hya (pH=3.5) caused that the most of the COO- groups of Hya were not dissociated, thus the gels were not formed. On the other hand, higher pH (pH=9) resulted

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10403 - Physical chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů