Microcalorimetry as an Effective Tool for the Determination of Thermodynamic Characteristics of Fulvic–Drug Interactions

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F24%3APU154966" target="_blank" >RIV/00216305:26310/24:PU154966 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.mdpi.com/2227-9717/13/1/49" target="_blank" >https://www.mdpi.com/2227-9717/13/1/49</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/pr13010049" target="_blank" >10.3390/pr13010049</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Microcalorimetry as an Effective Tool for the Determination of Thermodynamic Characteristics of Fulvic–Drug Interactions

Popis výsledku v původním jazyce

The presence of pharmaceuticals in the environment can result in potentially dangerous situations. In soils and sediments, pharmaceuticals can be partially immobilized by interactions with humic substances. Interactions, thus, can strongly affect their mobility and bioavailability. An investigation of the thermodynamic aspects of the interactions is largely missing. Thermodynamic parameters are usually calculated on the basis of sorption experiments. Our study is focused on the direct measurements of the heat effect of interactions between fulvic acids and chosen drugs. Well-characterized fulvic sample standards provided by the International Humic Substances Society were used. Ibuprofen, diclofenac, and sulphapyridine were chosen as drugs. Isothermal titration calorimetry provided a complete set of thermodynamic characteristics of underlying processes—interaction enthalpy, entropy, and Gibbs energy. All studied interactions were found to be exothermic with heat liberation between −496 and −9938 J/mol. The lowest enthalpies were obtained for sulphapyridine and the highest ones for ibuprofen (on average). Changes in Gibbs energy were very similar for all studied interactions (20–28 kJ/mol). The highest change in entropy was determined for ibuprofen (73 J/mol·K); values obtained for diclofenac and sulphapyridine were comparable (57 and 56 J/mol·K, respectively).

Název v anglickém jazyce

Microcalorimetry as an Effective Tool for the Determination of Thermodynamic Characteristics of Fulvic–Drug Interactions

Popis výsledku anglicky

The presence of pharmaceuticals in the environment can result in potentially dangerous situations. In soils and sediments, pharmaceuticals can be partially immobilized by interactions with humic substances. Interactions, thus, can strongly affect their mobility and bioavailability. An investigation of the thermodynamic aspects of the interactions is largely missing. Thermodynamic parameters are usually calculated on the basis of sorption experiments. Our study is focused on the direct measurements of the heat effect of interactions between fulvic acids and chosen drugs. Well-characterized fulvic sample standards provided by the International Humic Substances Society were used. Ibuprofen, diclofenac, and sulphapyridine were chosen as drugs. Isothermal titration calorimetry provided a complete set of thermodynamic characteristics of underlying processes—interaction enthalpy, entropy, and Gibbs energy. All studied interactions were found to be exothermic with heat liberation between −496 and −9938 J/mol. The lowest enthalpies were obtained for sulphapyridine and the highest ones for ibuprofen (on average). Changes in Gibbs energy were very similar for all studied interactions (20–28 kJ/mol). The highest change in entropy was determined for ibuprofen (73 J/mol·K); values obtained for diclofenac and sulphapyridine were comparable (57 and 56 J/mol·K, respectively).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

<a href="/cs/project/LO1211" target="_blank" >LO1211: Centrum materiálového výzkumu na FCH VUT v Brně - udržitelnost a rozvoj</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Processes

ISSN

2227-9717

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

11

Strana od-do

„“-„“

Kód UT WoS článku

001403837100001

EID výsledku v databázi Scopus

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