Preparation and Characterization of Cationic Vesicles from a New Type of Ion Pair Amphiphile Carbethopendecinium-Dodecylsulfate

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F26%3A0198943" target="_blank" >RIV/00216305:26310/26:0198943 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.acs.org/doi/full/10.1021/acs.langmuir.4c04795" target="_blank" >https://pubs.acs.org/doi/full/10.1021/acs.langmuir.4c04795</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.langmuir.4c04795" target="_blank" >10.1021/acs.langmuir.4c04795</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Preparation and Characterization of Cationic Vesicles from a New Type of Ion Pair Amphiphile Carbethopendecinium-Dodecylsulfate

Popis výsledku v původním jazyce

The aim of this work was to prepare and characterize a yet undescribed type of catanionic vesicle based on a new ion pair amphiphile, which were formed from carbethopendecinium bromide (also called Septonex) and sodium dodecylsulfate. The vesicles were prepared by mixing an amphiphilic pair together with dioctadecyldimethylammonium chloride and cholesterol at a concentration of 0, 5, 10, 15, 20, 30, 40, and 60 mol %. Final size, polydispersity and stability was studied by dynamic and electrophoretic light scattering. Fluorescence anisotropy, generalized polarization and high-resolution ultrasound spectroscopy were used to determine membrane order and hydration their outer part. The vesicles appeared to be stable in the short term independently of the cholesterol content. From a long-term (28 days) perspective, it was possible to detect a threshold of 15 mol % above which the vesicles were stable. The same cholesterol content threshold also applied to stability at elevated temperatures. Fluorescence measurements showed that the phase transition temperature was located at significantly lower temperatures compared to a similar system composed of hexadecyl-trimethylammonium-dodecyl sulfate. Using differential scanning calorimetry, it was found that this temperature was slightly affected by the cholesterol content and was around 15 degrees C. The results from ultrasonic spectroscopy together with generalized polarization and anisotropy showed a threshold of 20 mol % cholesterol content, above which the properties of the vesicular membrane, such as its stiffness and hydration, began to change significantly.

Název v anglickém jazyce

Preparation and Characterization of Cationic Vesicles from a New Type of Ion Pair Amphiphile Carbethopendecinium-Dodecylsulfate

Popis výsledku anglicky

The aim of this work was to prepare and characterize a yet undescribed type of catanionic vesicle based on a new ion pair amphiphile, which were formed from carbethopendecinium bromide (also called Septonex) and sodium dodecylsulfate. The vesicles were prepared by mixing an amphiphilic pair together with dioctadecyldimethylammonium chloride and cholesterol at a concentration of 0, 5, 10, 15, 20, 30, 40, and 60 mol %. Final size, polydispersity and stability was studied by dynamic and electrophoretic light scattering. Fluorescence anisotropy, generalized polarization and high-resolution ultrasound spectroscopy were used to determine membrane order and hydration their outer part. The vesicles appeared to be stable in the short term independently of the cholesterol content. From a long-term (28 days) perspective, it was possible to detect a threshold of 15 mol % above which the vesicles were stable. The same cholesterol content threshold also applied to stability at elevated temperatures. Fluorescence measurements showed that the phase transition temperature was located at significantly lower temperatures compared to a similar system composed of hexadecyl-trimethylammonium-dodecyl sulfate. Using differential scanning calorimetry, it was found that this temperature was slightly affected by the cholesterol content and was around 15 degrees C. The results from ultrasonic spectroscopy together with generalized polarization and anisotropy showed a threshold of 20 mol % cholesterol content, above which the properties of the vesicular membrane, such as its stiffness and hydration, began to change significantly.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Langmuir

ISSN

0743-7463

e-ISSN

1520-5827

Svazek periodika

16

Číslo periodika v rámci svazku

41

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

10135-10144

Kód UT WoS článku

001467572100001

EID výsledku v databázi Scopus

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