Study of cholesterol’s effect on the properties of catanionic vesicular systems

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F21%3APU141581" target="_blank" >RIV/00216305:26310/21:PU141581 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26310/20:PU138776

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Study of cholesterol’s effect on the properties of catanionic vesicular systems

Popis výsledku v původním jazyce

This work is focused on the study of properties and stability catanionic vesicles at laboratory temperature. Catanionic vesicles were based on the ion pair amphiphile (IPA), which was prepared by mixing equivalent volumes of aqueous solution HTMAB (hexadecyltrimethylammonium bromide) and SDS (sodium dodecylsulphate). Then the precipitate was obtained and after removal of the counterions of these surfactants, IPA was formed. The residue IPA was denoted as HTMA-DS. To improve stability positively charged double-chained dioctadecyldimethylammonium chloride (DODAC) and cholesterol were added. The total amount of cholesterol was set to 0, 3, 13, 23, 33, 43, 53, 63 and 73 mol.%. In this system, the size distribution was studied using the dynamic light-scattering (DLS) and zeta potential was determined by electrophoretic light-scattering. These standard techniques were supplemented by fluorescence spectroscopy technique. Specifically, generalized polarization (GP) was measured using a Laurdan probe. This pro

Název v anglickém jazyce

Study of cholesterol’s effect on the properties of catanionic vesicular systems

Popis výsledku anglicky

This work is focused on the study of properties and stability catanionic vesicles at laboratory temperature. Catanionic vesicles were based on the ion pair amphiphile (IPA), which was prepared by mixing equivalent volumes of aqueous solution HTMAB (hexadecyltrimethylammonium bromide) and SDS (sodium dodecylsulphate). Then the precipitate was obtained and after removal of the counterions of these surfactants, IPA was formed. The residue IPA was denoted as HTMA-DS. To improve stability positively charged double-chained dioctadecyldimethylammonium chloride (DODAC) and cholesterol were added. The total amount of cholesterol was set to 0, 3, 13, 23, 33, 43, 53, 63 and 73 mol.%. In this system, the size distribution was studied using the dynamic light-scattering (DLS) and zeta potential was determined by electrophoretic light-scattering. These standard techniques were supplemented by fluorescence spectroscopy technique. Specifically, generalized polarization (GP) was measured using a Laurdan probe. This pro

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10403 - Physical chemistry

Projekt

<a href="/cs/project/GC19-14024J" target="_blank" >GC19-14024J: Hyaluronan-kataniontové vezikulární komplexy - interakce, struktura, fyzikální vlastnosti a stabilita</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů