Interaction Between Catanionic Vesicles and Oppositely Charged Hyaluronan

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F21%3APU141954" target="_blank" >RIV/00216305:26310/21:PU141954 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Interaction Between Catanionic Vesicles and Oppositely Charged Hyaluronan

Popis výsledku v původním jazyce

This contribution is focused on the interaction between positively charged catanionic vesicles and oppositely charged hyaluronan. Catanionic vesicles are formed from so called ion pair amphiphiles (IPA). Charged catanionic vesicles can also bring another benefit in the interaction with oppositely charged (bio)polymers through electrostatic interactions. This interaction can also improve the higher stability and biocompatibility of vesicles. Polysaccharide hyaluronan, which as a polymer present in the human body is fully biocompatible and fully biodegradable, appears to be very suitable for this purpose. Vesicles were prepared from hexadecyltrimethylammonium bromide (HTMAB) and sodium dodecyl sulphate (SDS) and they were doped with positively charged dioctadecyldimethylammonium chloride (DODAC) and cholesterol. For interaction with them, hyaluronan of four different molecular weights (16, 418, 750, and 1670 kDa) was used. Size and ζ-potential titrations were used to characterize these interactions. The

Název v anglickém jazyce

Interaction Between Catanionic Vesicles and Oppositely Charged Hyaluronan

Popis výsledku anglicky

This contribution is focused on the interaction between positively charged catanionic vesicles and oppositely charged hyaluronan. Catanionic vesicles are formed from so called ion pair amphiphiles (IPA). Charged catanionic vesicles can also bring another benefit in the interaction with oppositely charged (bio)polymers through electrostatic interactions. This interaction can also improve the higher stability and biocompatibility of vesicles. Polysaccharide hyaluronan, which as a polymer present in the human body is fully biocompatible and fully biodegradable, appears to be very suitable for this purpose. Vesicles were prepared from hexadecyltrimethylammonium bromide (HTMAB) and sodium dodecyl sulphate (SDS) and they were doped with positively charged dioctadecyldimethylammonium chloride (DODAC) and cholesterol. For interaction with them, hyaluronan of four different molecular weights (16, 418, 750, and 1670 kDa) was used. Size and ζ-potential titrations were used to characterize these interactions. The

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10403 - Physical chemistry

Projekt

<a href="/cs/project/GC19-14024J" target="_blank" >GC19-14024J: Hyaluronan-kataniontové vezikulární komplexy - interakce, struktura, fyzikální vlastnosti a stabilita</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů