Interactions between Cationic Ion Pair Amphiphile Vesicles and Hyaluronan—A Physicochemical Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F21%3APU141175" target="_blank" >RIV/00216305:26310/21:PU141175 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs-acs-org.ezproxy.lib.vutbr.cz/doi/abs/10.1021/acs.langmuir.1c00993" target="_blank" >https://pubs-acs-org.ezproxy.lib.vutbr.cz/doi/abs/10.1021/acs.langmuir.1c00993</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.langmuir.1c00993" target="_blank" >10.1021/acs.langmuir.1c00993</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Interactions between Cationic Ion Pair Amphiphile Vesicles and Hyaluronan—A Physicochemical Study

Popis výsledku v původním jazyce

High-resolution ultrasound spectroscopy (HR-US), size and zeta-potential titrations, and isothermal titration calorimetry (ITC) were used to characterize the interactions between hyaluronan and catanionic ion pair amphiphile vesicles composed of hexadecyltrimethylammonium-dodecylsulphate (HTMA-DS), dioctadecyldimethylammonium chloride (DODAC), and cholesterol. In addition to these methods, visual observations were performed with the selected molecular weight of hyaluronan. A very good correlation was obtained between data from size titration, HR-US, and visual observation, which indicated in lower charge ratios the formation of hyaluronan-coated vesicles. On the contrary, at higher charge ratios, coated vesicles disintegrated to a size of around 2000 nm. The intensity of these interactions and the disaggregation were dependent on the molecular weight of hyaluronan. All interactions studied by ITC showed strong exothermic behavior, and these interactions between vesicles and hyaluronan were confirmed from the first addition, independently of the molecular weight of hyaluronan.

Název v anglickém jazyce

Interactions between Cationic Ion Pair Amphiphile Vesicles and Hyaluronan—A Physicochemical Study

Popis výsledku anglicky

High-resolution ultrasound spectroscopy (HR-US), size and zeta-potential titrations, and isothermal titration calorimetry (ITC) were used to characterize the interactions between hyaluronan and catanionic ion pair amphiphile vesicles composed of hexadecyltrimethylammonium-dodecylsulphate (HTMA-DS), dioctadecyldimethylammonium chloride (DODAC), and cholesterol. In addition to these methods, visual observations were performed with the selected molecular weight of hyaluronan. A very good correlation was obtained between data from size titration, HR-US, and visual observation, which indicated in lower charge ratios the formation of hyaluronan-coated vesicles. On the contrary, at higher charge ratios, coated vesicles disintegrated to a size of around 2000 nm. The intensity of these interactions and the disaggregation were dependent on the molecular weight of hyaluronan. All interactions studied by ITC showed strong exothermic behavior, and these interactions between vesicles and hyaluronan were confirmed from the first addition, independently of the molecular weight of hyaluronan.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

<a href="/cs/project/GC19-14024J" target="_blank" >GC19-14024J: Hyaluronan-kataniontové vezikulární komplexy - interakce, struktura, fyzikální vlastnosti a stabilita</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Langmuir

ISSN

0743-7463

e-ISSN

1520-5827

Svazek periodika

37

Číslo periodika v rámci svazku

28

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

8525-8533

Kód UT WoS článku

000695298500017

EID výsledku v databázi Scopus

2-s2.0-85110990780