Synthetic peptide mediated immunoconjugation of quantum dots

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Synthetic peptide mediated immunoconjugation of quantum dots

Popis výsledku v původním jazyce

Quantum dots (QDs) are nanoparticles with the dimensions in the range of 2-10 nm. They are used as a fluorescent label in a variety of biological investigations. QDs have a broad absorption with narrow photoluminescence spectra, high resistance to photobleaching and high resistance to photo-and chemical degradation. Nowadays, they are usually made of semiconductor core capped with any organic derivative making the quantum dot water soluble. This organic compound covering the metal core also serves as a linker for further conjugation. Up to now, many efforts have been made to utilize quantum dots as immunochemical sensor. One of the possible ways is to conjugate the quantum dot with antibody. There are several methods of immuno-quantum dot preparation. The conjugation of antibodies or proteins to quantum dots using standard linking chemistry can be related to potential difficulties of working with nanoparticles. We have investigated an alternative approach of self-assembled immuno-quantum dot preparation using a peptide as a linker.

Název v anglickém jazyce

Synthetic peptide mediated immunoconjugation of quantum dots

Popis výsledku anglicky

Quantum dots (QDs) are nanoparticles with the dimensions in the range of 2-10 nm. They are used as a fluorescent label in a variety of biological investigations. QDs have a broad absorption with narrow photoluminescence spectra, high resistance to photobleaching and high resistance to photo-and chemical degradation. Nowadays, they are usually made of semiconductor core capped with any organic derivative making the quantum dot water soluble. This organic compound covering the metal core also serves as a linker for further conjugation. Up to now, many efforts have been made to utilize quantum dots as immunochemical sensor. One of the possible ways is to conjugate the quantum dot with antibody. There are several methods of immuno-quantum dot preparation. The conjugation of antibodies or proteins to quantum dots using standard linking chemistry can be related to potential difficulties of working with nanoparticles. We have investigated an alternative approach of self-assembled immuno-quantum dot preparation using a peptide as a linker.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

20601 - Medical engineering

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

MENDELNET 2012

ISBN

978-80-7375-836-3

ISSN

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e-ISSN

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Počet stran výsledku

10

Strana od-do

1190-1199

Název nakladatele

Neuveden

Místo vydání

Neuveden

Místo konání akce

Mendel Univ, Fac Agron, Brno

Datum konání akce

21. 11. 2012

Typ akce podle státní příslušnosti

CST - Celostátní akce

Kód UT WoS článku

000366461200139