PROFILE COMPARSION OF ZINC-PROTEINS IN CANCER AND CONTROL PROSTATIC CELLS EXPOSED A ZN(II)

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

PROFILE COMPARSION OF ZINC-PROTEINS IN CANCER AND CONTROL PROSTATIC CELLS EXPOSED A ZN(II)

Popis výsledku v původním jazyce

The aim of this study is compare the profile of zinc-proteins level of potential tumour markers in the cell lines PC-3, LNCaP and PNT1A. Zinc plays an important role in the healthy prostatic tissue. It is necessary for the proliferation, differentiation, regulation and apoptosis of the cells. Prostatic healthy tissue accumulate zinc in the cells of the lateral lobes in the prostate. Cancer prostatic tissue loses this ability. Cell lines PC-3 and LNCaP represent prostate cancer and line PNT1A represent healthy and control prostate tissue. We have developed automatic and fast method of the isolation of zinc-proteins from prostatic cells by magnetic particles modified by specific antibody. Zinc was measured by the electrochemical method - differential pulse voltammetry. We determined 15% decreased level of zinc in prostate cancer patients than in the control healthy prostatic cells.

Název v anglickém jazyce

PROFILE COMPARSION OF ZINC-PROTEINS IN CANCER AND CONTROL PROSTATIC CELLS EXPOSED A ZN(II)

Popis výsledku anglicky

The aim of this study is compare the profile of zinc-proteins level of potential tumour markers in the cell lines PC-3, LNCaP and PNT1A. Zinc plays an important role in the healthy prostatic tissue. It is necessary for the proliferation, differentiation, regulation and apoptosis of the cells. Prostatic healthy tissue accumulate zinc in the cells of the lateral lobes in the prostate. Cancer prostatic tissue loses this ability. Cell lines PC-3 and LNCaP represent prostate cancer and line PNT1A represent healthy and control prostate tissue. We have developed automatic and fast method of the isolation of zinc-proteins from prostatic cells by magnetic particles modified by specific antibody. Zinc was measured by the electrochemical method - differential pulse voltammetry. We determined 15% decreased level of zinc in prostate cancer patients than in the control healthy prostatic cells.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30204 - Oncology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

MENDELNET 2012

ISBN

978-80-7375-836-3

ISSN

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e-ISSN

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Počet stran výsledku

8

Strana od-do

949-956

Název nakladatele

Neuveden

Místo vydání

Neuveden

Místo konání akce

Mendel Univ, Fac Agron, Brno

Datum konání akce

21. 11. 2012

Typ akce podle státní příslušnosti

CST - Celostátní akce

Kód UT WoS článku

000366461200109