ANALYSIS OF DOXORUBICIN ENCAPSULATION IN APOFERRITIN CAGE BY CAPILLARY ELECTROPHORESIS WITH LASER-INDUCED FLUORESCENCE DETECTION

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F12%3APU127016" target="_blank" >RIV/00216305:26620/12:PU127016 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

ANALYSIS OF DOXORUBICIN ENCAPSULATION IN APOFERRITIN CAGE BY CAPILLARY ELECTROPHORESIS WITH LASER-INDUCED FLUORESCENCE DETECTION

Popis výsledku v původním jazyce

Doxorubicin is an effective cytostatic drug used for treatment of some leukemias and Hodgkin's lymphoma, as well as cancers of the bladder, breast, stomach, lung, ovaries, thyroid, soft tissue sarcoma and/or multiple myeloma. Even though this drug is effective for cancer treatment its toxicity, mainly cardiotoxicity, is limiting the use. For this reason, encapsulation of the drug into the biocarriers, lowering the toxicity, is widely investigated. One of such carriers may be a protein called apoferritin, which is due to the cavity in its structure, able to incept the molecule of interest. Subsequent decrease of pH leads to the opening of the structure and release of the content. The aim of this study is to investigate the behavior of the encapsulated doxorubicin using capillary electrophoresis with laser-induced fluorescence detection (CE-LIF).

Název v anglickém jazyce

ANALYSIS OF DOXORUBICIN ENCAPSULATION IN APOFERRITIN CAGE BY CAPILLARY ELECTROPHORESIS WITH LASER-INDUCED FLUORESCENCE DETECTION

Popis výsledku anglicky

Doxorubicin is an effective cytostatic drug used for treatment of some leukemias and Hodgkin's lymphoma, as well as cancers of the bladder, breast, stomach, lung, ovaries, thyroid, soft tissue sarcoma and/or multiple myeloma. Even though this drug is effective for cancer treatment its toxicity, mainly cardiotoxicity, is limiting the use. For this reason, encapsulation of the drug into the biocarriers, lowering the toxicity, is widely investigated. One of such carriers may be a protein called apoferritin, which is due to the cavity in its structure, able to incept the molecule of interest. Subsequent decrease of pH leads to the opening of the structure and release of the content. The aim of this study is to investigate the behavior of the encapsulated doxorubicin using capillary electrophoresis with laser-induced fluorescence detection (CE-LIF).

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

10406 - Analytical chemistry

Projekt

<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

CECE 2012

ISBN

978-80-904959-1-3

ISSN

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e-ISSN

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Počet stran výsledku

4

Strana od-do

209-212

Název nakladatele

Neuveden

Místo vydání

Neuveden

Místo konání akce

Brno

Datum konání akce

31. 10. 2012

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000329635000061