STRENGTH DEGRADATION OF CALCIUM PHOSPHATE SCAFFOLDS UNDER CONDITIONS SIMULATING OSTEOCLASTIC RESORPTION

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

STRENGTH DEGRADATION OF CALCIUM PHOSPHATE SCAFFOLDS UNDER CONDITIONS SIMULATING OSTEOCLASTIC RESORPTION

Popis výsledku v původním jazyce

Calcium phosphates (CaPs) ceramics are the first-choice material for large bone defect healing. Scaffolds prepared from CaPs must fulfill many demands. One of these demands is bioresorbability of the scaffold material. In case of sintered ceramic scaffolds the only degradation mechanism (at least at the beginning of the resorption) is acidic mechanism mediated by osteoclasts. This degradation leads inevitably to the loss of mechanical strength. The loss of mechanical strength should be continual and match the growth of the new bone tissue. Within the scope of our research we present results of the mechanical strength degradation of the three types of highly porous CaPs scaffolds. Hydroxyapatite (HA), tricalcium phosphate (TCP) and biphasic calcium phosphate (BCP) scaffolds with similar porosity (over 80%) and pore size were tested. Samples were exposed to slightly acidic environment of the McIlvaine buffer (pH 5.5) at a temperature of 37 °C. Strength degradation, phase and morphological changes were

Název v anglickém jazyce

STRENGTH DEGRADATION OF CALCIUM PHOSPHATE SCAFFOLDS UNDER CONDITIONS SIMULATING OSTEOCLASTIC RESORPTION

Popis výsledku anglicky

Calcium phosphates (CaPs) ceramics are the first-choice material for large bone defect healing. Scaffolds prepared from CaPs must fulfill many demands. One of these demands is bioresorbability of the scaffold material. In case of sintered ceramic scaffolds the only degradation mechanism (at least at the beginning of the resorption) is acidic mechanism mediated by osteoclasts. This degradation leads inevitably to the loss of mechanical strength. The loss of mechanical strength should be continual and match the growth of the new bone tissue. Within the scope of our research we present results of the mechanical strength degradation of the three types of highly porous CaPs scaffolds. Hydroxyapatite (HA), tricalcium phosphate (TCP) and biphasic calcium phosphate (BCP) scaffolds with similar porosity (over 80%) and pore size were tested. Samples were exposed to slightly acidic environment of the McIlvaine buffer (pH 5.5) at a temperature of 37 °C. Strength degradation, phase and morphological changes were

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20504 - Ceramics

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů