Bioactive TiCaPCON-coated PCL nanofibers as a promising material for bone tissue engineering

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F19%3APU134663" target="_blank" >RIV/00216305:26620/19:PU134663 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/19:00113735

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0169433219305057?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0169433219305057?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.apsusc.2019.02.163" target="_blank" >10.1016/j.apsusc.2019.02.163</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Bioactive TiCaPCON-coated PCL nanofibers as a promising material for bone tissue engineering

Popis výsledku v původním jazyce

This work deals with the deposition of bioactive TiCaPCON films onto biodegradable polycaprolactone (PCL) nanofibers using magnetron sputtering for bone tissue engineering. Low melting point of PCL nanofibers requires a careful tuning of processing parameters in order to achieve high film quality and avoid substrate degradation. SEM and XPS analyses showed that, with the magnetron current of 2 A, the TiCaPCON films deposited onto PCL nanofibers and Si wafers exhibit similar chemical states hereby indicating that the nanofiber structure is not affected by the deposition process. In vitro biological tests indicated that the osteoblasts adhesion and proliferation as well the ALP activity can be significantly improved by depositing the TiCaPCON film onto PCL. The reported findings suggest a new strategy for the preparation of biodegradable polymer-based biomaterials for bone tissue engineering.

Název v anglickém jazyce

Bioactive TiCaPCON-coated PCL nanofibers as a promising material for bone tissue engineering

Popis výsledku anglicky

This work deals with the deposition of bioactive TiCaPCON films onto biodegradable polycaprolactone (PCL) nanofibers using magnetron sputtering for bone tissue engineering. Low melting point of PCL nanofibers requires a careful tuning of processing parameters in order to achieve high film quality and avoid substrate degradation. SEM and XPS analyses showed that, with the magnetron current of 2 A, the TiCaPCON films deposited onto PCL nanofibers and Si wafers exhibit similar chemical states hereby indicating that the nanofiber structure is not affected by the deposition process. In vitro biological tests indicated that the osteoblasts adhesion and proliferation as well the ALP activity can be significantly improved by depositing the TiCaPCON film onto PCL. The reported findings suggest a new strategy for the preparation of biodegradable polymer-based biomaterials for bone tissue engineering.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10403 - Physical chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Applied Surface Science

ISSN

0169-4332

e-ISSN

1873-5584

Svazek periodika

479

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

796-802

Kód UT WoS článku

000464931800097

EID výsledku v databázi Scopus

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