Challenges in the laser ablation of soft tissues

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F20%3APU137841" target="_blank" >RIV/00216305:26620/20:PU137841 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26620/20:PU137847

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Challenges in the laser ablation of soft tissues

Popis výsledku v původním jazyce

The main benefit of laser-induced breakdown spectroscopy (LIBS) in elemental imaging of biological samples is namely the capability to provide large scale analysis (i.e. whole slide imaging). Thus, LIBS may serve as a complementary technique providing a fast scan of the sample and guiding the researcher in further analysis across applications, incl. cancer research. However, elemental imaging of biological samples still remains a challenging task, mainly due to the soft nature of biological tissues and its heterogeneous composition. [1] Laser-tissue interaction is a complex phenomenon that is simultaneously influenced by several parameters (laser energy, spot size, ambient atmosphere, etc.). Thus, in our work, we have suggested a way how to prepare and optimize soft-tissue samples in order to get the best possible analytical signal response. Concurrently, we aim to stick to the histological preparation of the sample while it is a golden standard used in clinical research. Therefore, we only used paraf

Název v anglickém jazyce

Challenges in the laser ablation of soft tissues

Popis výsledku anglicky

The main benefit of laser-induced breakdown spectroscopy (LIBS) in elemental imaging of biological samples is namely the capability to provide large scale analysis (i.e. whole slide imaging). Thus, LIBS may serve as a complementary technique providing a fast scan of the sample and guiding the researcher in further analysis across applications, incl. cancer research. However, elemental imaging of biological samples still remains a challenging task, mainly due to the soft nature of biological tissues and its heterogeneous composition. [1] Laser-tissue interaction is a complex phenomenon that is simultaneously influenced by several parameters (laser energy, spot size, ambient atmosphere, etc.). Thus, in our work, we have suggested a way how to prepare and optimize soft-tissue samples in order to get the best possible analytical signal response. Concurrently, we aim to stick to the histological preparation of the sample while it is a golden standard used in clinical research. Therefore, we only used paraf

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10406 - Analytical chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů