Imaging of Biological Tissues

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F22%3APU147827" target="_blank" >RIV/00216305:26620/22:PU147827 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/chapter/10.1007/978-3-031-14502-5_6" target="_blank" >https://link.springer.com/chapter/10.1007/978-3-031-14502-5_6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-031-14502-5_6" target="_blank" >10.1007/978-3-031-14502-5_6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Imaging of Biological Tissues

Popis výsledku v původním jazyce

Laser-Induced Breakdown Spectroscopy (LIBS) has established its position as a method for the analysis of biological samples. We aim to introduce the benefits of LIBS for the qualitative elemental imaging of tissues. The state-of-the-art instrumentation enables elemental imaging of sample surfaces with a high resolution (down to micro-scale) on a large scale (up to a whole-slide image), i.e., megapixel imaging of the distribution of investigated elements. The implementation of this promising tool to the analytical pipeline in various fields (from developmental biology to clinical research) is discussed. The typical interpretation of LIBS results through basic spectroscopic algorithms and machine learning is dissected. The chapter reviews recent advances of LIBS namely in soft and hard tissue analyses when the detection of endogenous and exogenous elements (major and trace metals) is concerned. The comparison to other elemental imaging methods (namely Laser Ablation Inductively Coupled Plasma Mass Spectrometry) is given. Finally, future perspectives and development of LIBS bioimaging is suggested.

Název v anglickém jazyce

Imaging of Biological Tissues

Popis výsledku anglicky

Laser-Induced Breakdown Spectroscopy (LIBS) has established its position as a method for the analysis of biological samples. We aim to introduce the benefits of LIBS for the qualitative elemental imaging of tissues. The state-of-the-art instrumentation enables elemental imaging of sample surfaces with a high resolution (down to micro-scale) on a large scale (up to a whole-slide image), i.e., megapixel imaging of the distribution of investigated elements. The implementation of this promising tool to the analytical pipeline in various fields (from developmental biology to clinical research) is discussed. The typical interpretation of LIBS results through basic spectroscopic algorithms and machine learning is dissected. The chapter reviews recent advances of LIBS namely in soft and hard tissue analyses when the detection of endogenous and exogenous elements (major and trace metals) is concerned. The comparison to other elemental imaging methods (namely Laser Ablation Inductively Coupled Plasma Mass Spectrometry) is given. Finally, future perspectives and development of LIBS bioimaging is suggested.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10406 - Analytical chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Laser-Induced Breakdown Spectroscopy in Biological, Forensic and Materials Sciences

ISBN

978-3-031-14502-5

Počet stran výsledku

26

Strana od-do

„“-„“

Počet stran knihy

313

Název nakladatele

Neuveden

Místo vydání

Neuveden

Kód UT WoS kapitoly

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