Chemical Microrobots as Self-Propelled Microbrushes against Dental Biofilm

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F20%3APU138406" target="_blank" >RIV/00216305:26620/20:PU138406 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22310/20:43920513 RIV/60461373:22330/20:43920513

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S2666386420301922" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2666386420301922</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.xcrp.2020.100181" target="_blank" >10.1016/j.xcrp.2020.100181</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chemical Microrobots as Self-Propelled Microbrushes against Dental Biofilm

Popis výsledku v původním jazyce

Mouths offer the perfect environments for microbial cell formation, promoting the growth of biofilms, for example, on teeth. Dental biofilm exhibits strong resistance to antibiotics and is a cause of many dental diseases. Common strategies for dental biofilm removal involve the addition of high concentrations of hydrogen peroxide (H2O2), which increases tooth sensitivity, or mechanical procedures. Here, we report a different approach based on self-propelled micromachines with high antibacterial activity for the degradation of dental biofilm. Such microrobots use low concentrations of fuel for their propulsion, and they achieve an efficient dental biofilm disruption in only 5 min of treatment. Moreover, these microrobots are biocompatible with epidermal and organ cells and may stimulate the immune system to fight against microbial infection. This approach of exploiting the active motion of bubble-propelled catalytic micromachines for oral biofilm disruption may open the door for more efficient and sophisticated treatments in dentistry.

Název v anglickém jazyce

Chemical Microrobots as Self-Propelled Microbrushes against Dental Biofilm

Popis výsledku anglicky

Mouths offer the perfect environments for microbial cell formation, promoting the growth of biofilms, for example, on teeth. Dental biofilm exhibits strong resistance to antibiotics and is a cause of many dental diseases. Common strategies for dental biofilm removal involve the addition of high concentrations of hydrogen peroxide (H2O2), which increases tooth sensitivity, or mechanical procedures. Here, we report a different approach based on self-propelled micromachines with high antibacterial activity for the degradation of dental biofilm. Such microrobots use low concentrations of fuel for their propulsion, and they achieve an efficient dental biofilm disruption in only 5 min of treatment. Moreover, these microrobots are biocompatible with epidermal and organ cells and may stimulate the immune system to fight against microbial infection. This approach of exploiting the active motion of bubble-propelled catalytic micromachines for oral biofilm disruption may open the door for more efficient and sophisticated treatments in dentistry.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30404 - Biomaterials (as related to medical implants, devices, sensors)

Projekt

<a href="/cs/project/LL2002" target="_blank" >LL2002: Autonomní Inteligentní Roje Mikroplavců</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cell Reports Physical Science

ISSN

2666-3864

e-ISSN

—

Svazek periodika

1

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

18

Strana od-do

1-18

Kód UT WoS článku

000658752300008

EID výsledku v databázi Scopus

2-s2.0-85099015099