Microrobotic carrier with enzymatically encoded drug release in the presence of pancreatic cancer cells via programmed self-destruction
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F22%3A43924095" target="_blank" >RIV/60461373:22310/22:43924095 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/60461373:22330/22:43924095 RIV/60461373:22350/22:43924095
Výsledek na webu
<a href="https://www.sciencedirect.com/science/article/pii/S2352940722001299" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2352940722001299</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.apmt.2022.101494" target="_blank" >10.1016/j.apmt.2022.101494</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Microrobotic carrier with enzymatically encoded drug release in the presence of pancreatic cancer cells via programmed self-destruction
Popis výsledku v původním jazyce
The field of micro/nanorobots is at the forefront of nanotechnology research. Particularly, magnetically propelled micro/nanorobots demonstrate great potential for biomedical applications due to their biocompatibility in biological environments. Herein is a concept of magnetically powered micromachines with a biodegradable polymer and layer containing an incorporated anticancer drug. The microrobot is chemically programmed in such a way that the polymer layer is degraded by the enzymatic activity of lipase, which is overexpressed in pancreatic cancer cells. This causes degradation of the microrobot's polymer layer and, thus, destruction of this robot, releasing the anticancer drug, which in turn kills the pancreatic cancer cell. Magnetic microrobots are based on microspheres made of polycaprolactone (PCL), iron oxide nanoparticles (Fe3O4), and coated polyethyleneimine (PEI) micelles containing the anticancer drug. Lipase, naturally overexpressed specifically in pancreatic cancer cells, triggers the drug release from the micromachines through biodegradation of PCL. The developed PCL-Fe3O4/PEI magnetic microrobots are fully biocompatible and represent a promising tool for programmable drug release that may be useful in many biomedical applications. © 2022
Název v anglickém jazyce
Microrobotic carrier with enzymatically encoded drug release in the presence of pancreatic cancer cells via programmed self-destruction
Popis výsledku anglicky
The field of micro/nanorobots is at the forefront of nanotechnology research. Particularly, magnetically propelled micro/nanorobots demonstrate great potential for biomedical applications due to their biocompatibility in biological environments. Herein is a concept of magnetically powered micromachines with a biodegradable polymer and layer containing an incorporated anticancer drug. The microrobot is chemically programmed in such a way that the polymer layer is degraded by the enzymatic activity of lipase, which is overexpressed in pancreatic cancer cells. This causes degradation of the microrobot's polymer layer and, thus, destruction of this robot, releasing the anticancer drug, which in turn kills the pancreatic cancer cell. Magnetic microrobots are based on microspheres made of polycaprolactone (PCL), iron oxide nanoparticles (Fe3O4), and coated polyethyleneimine (PEI) micelles containing the anticancer drug. Lipase, naturally overexpressed specifically in pancreatic cancer cells, triggers the drug release from the micromachines through biodegradation of PCL. The developed PCL-Fe3O4/PEI magnetic microrobots are fully biocompatible and represent a promising tool for programmable drug release that may be useful in many biomedical applications. © 2022
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10402 - Inorganic and nuclear chemistry
Návaznosti výsledku
Projekt
<a href="/cs/project/NU21-08-00407" target="_blank" >NU21-08-00407: Funkční nanoroboti pro navigovanou kombinovanou nádorovou terapii</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2022
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Applied Materials Today
ISSN
2352-9407
e-ISSN
—
Svazek periodika
27
Číslo periodika v rámci svazku
JUN 2022
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
9
Strana od-do
nestrankovano
Kód UT WoS článku
000804754900001
EID výsledku v databázi Scopus
2-s2.0-85129966877