Cooperative Multifunctional Self-Propelled Paramagnetic Microrobots with Chemical Handles for Cell Manipulation and Drug Delivery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F18%3A43914231" target="_blank" >RIV/62156489:43210/18:43914231 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22310/18:43915743 RIV/00216305:26620/18:PU131599

Výsledek na webu

<a href="https://doi.org/10.1002/adfm.201804343" target="_blank" >https://doi.org/10.1002/adfm.201804343</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/adfm.201804343" target="_blank" >10.1002/adfm.201804343</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cooperative Multifunctional Self-Propelled Paramagnetic Microrobots with Chemical Handles for Cell Manipulation and Drug Delivery

Popis výsledku v původním jazyce

Autonomous self-propelled micromachines, taking energy from surrounding environment and converting it to their motion, are on the forefront of the research for smart materials in the recent years. Owing to their self-propulsion mechanism, they have demonstrated to be more efficient drug carriers than passive particles. Here, multifunctional superparamagnetic/catalytic microrobots (PM/Pt microrobots) for cell manipulation, anticancer drug loading, and delivery to breast cancer cells are presented. These PM/Pt microrobots are fabricated from superparamagnetic polymer particles with iron oxide in their interior and an external tosylated surface, which is half-covered by a catalytic platinum (Pt) layer. This result in a triple-functionality-tosyl group-rich polymer layer can bind molecules and biological materials, Pt layer can catalyze decomposition of hydrogen peroxide, providing propulsion to the microrobots and magnetic part allows for manipulation by magnetic field. PM/Pt microrobots are able to move as individual robots and to team-up under influence of weak magnetic field by forming chains of the micromachines to perform collective actions, such as capture and transportation of cancer cells. The efficacy of PM/Pt microrobots to perform several tasks without complex surface functionalization steps simplifies the applicability of such multifunctional devices toward diverse biomedical applications.

Název v anglickém jazyce

Cooperative Multifunctional Self-Propelled Paramagnetic Microrobots with Chemical Handles for Cell Manipulation and Drug Delivery

Popis výsledku anglicky

Autonomous self-propelled micromachines, taking energy from surrounding environment and converting it to their motion, are on the forefront of the research for smart materials in the recent years. Owing to their self-propulsion mechanism, they have demonstrated to be more efficient drug carriers than passive particles. Here, multifunctional superparamagnetic/catalytic microrobots (PM/Pt microrobots) for cell manipulation, anticancer drug loading, and delivery to breast cancer cells are presented. These PM/Pt microrobots are fabricated from superparamagnetic polymer particles with iron oxide in their interior and an external tosylated surface, which is half-covered by a catalytic platinum (Pt) layer. This result in a triple-functionality-tosyl group-rich polymer layer can bind molecules and biological materials, Pt layer can catalyze decomposition of hydrogen peroxide, providing propulsion to the microrobots and magnetic part allows for manipulation by magnetic field. PM/Pt microrobots are able to move as individual robots and to team-up under influence of weak magnetic field by forming chains of the micromachines to perform collective actions, such as capture and transportation of cancer cells. The efficacy of PM/Pt microrobots to perform several tasks without complex surface functionalization steps simplifies the applicability of such multifunctional devices toward diverse biomedical applications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30107 - Medicinal chemistry

Projekt

<a href="/cs/project/GA16-18917S" target="_blank" >GA16-18917S: Studium metabolismu sarkosinu a jeho participace na vývoji nádorů prostaty</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Advanced Functional Materials

ISSN

1616-301X

e-ISSN

—

Svazek periodika

28

Číslo periodika v rámci svazku

43

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

"nestrankovano"

Kód UT WoS článku

000448258800012

EID výsledku v databázi Scopus

2-s2.0-85052965532