Micellar electrokinetic chromatography as a powerful analytical tool for research on prebiotic chemistry

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F21%3APU141130" target="_blank" >RIV/00216305:26620/21:PU141130 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388955:_____/21:00543635

Výsledek na webu

<a href="https://doi.org/10.1016/j.microc.2021.106022" target="_blank" >https://doi.org/10.1016/j.microc.2021.106022</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.microc.2021.106022" target="_blank" >10.1016/j.microc.2021.106022</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Micellar electrokinetic chromatography as a powerful analytical tool for research on prebiotic chemistry

Popis výsledku v původním jazyce

Capillary electromigration techniques have proven their capabilities in detection of variety of analytes from inorganic ions and small organic molecules through bio(macro)molecules to large analytes such as cells or nano/ micro particles. Also broad range of potential applications includes food and environmental analysis, biomedical and pharmaceutical investigations or even diagnostics. In this work, it was demonstrated that capillary micellar electrokinetic chromatography is an excellent tool extremely helpful in investigations focused on prebiotic synthesis of molecules essential for formation of life on early Earth & ndash; nucleobases. In particular, rapid separation of nucleobases (< 2 min) was achieved in 40 mM borate buffer separation electrolyte containing 60 mM sodium dodecyl sulfate as an additive. This approach enabled detection of nucleobases formed in thermolysed formamide under conditions simulating the environment occurring on early Earth. Moreover, polydopamine-based molecularly imprinted polymers specific to thymine and uracil improved detection of these low abundant products

Název v anglickém jazyce

Micellar electrokinetic chromatography as a powerful analytical tool for research on prebiotic chemistry

Popis výsledku anglicky

Capillary electromigration techniques have proven their capabilities in detection of variety of analytes from inorganic ions and small organic molecules through bio(macro)molecules to large analytes such as cells or nano/ micro particles. Also broad range of potential applications includes food and environmental analysis, biomedical and pharmaceutical investigations or even diagnostics. In this work, it was demonstrated that capillary micellar electrokinetic chromatography is an excellent tool extremely helpful in investigations focused on prebiotic synthesis of molecules essential for formation of life on early Earth & ndash; nucleobases. In particular, rapid separation of nucleobases (< 2 min) was achieved in 40 mM borate buffer separation electrolyte containing 60 mM sodium dodecyl sulfate as an additive. This approach enabled detection of nucleobases formed in thermolysed formamide under conditions simulating the environment occurring on early Earth. Moreover, polydopamine-based molecularly imprinted polymers specific to thymine and uracil improved detection of these low abundant products

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10406 - Analytical chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

MICROCHEMICAL JOURNAL

ISSN

0026-265X

e-ISSN

1095-9149

Svazek periodika

167

Číslo periodika v rámci svazku

106022

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

1-7

Kód UT WoS článku

000662640500005

EID výsledku v databázi Scopus

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