Micellar electrokinetic chromatography as a powerful analytical tool for research on prebiotic chemistry

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F21%3A00543635" target="_blank" >RIV/61388955:_____/21:00543635 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26620/21:PU141130

Výsledek na webu

<a href="http://hdl.handle.net/11104/0320824" target="_blank" >http://hdl.handle.net/11104/0320824</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.microc.2021.106022" target="_blank" >10.1016/j.microc.2021.106022</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Micellar electrokinetic chromatography as a powerful analytical tool for research on prebiotic chemistry

Popis výsledku v původním jazyce

Capillary electromigration techniques have proven their capabilities in detection of variety of analytes from inorganic ions and small organic molecules through bio(macro)molecules to large analytes such as cells or nano/ micro particles. Also broad range of potential applications includes food and environmental analysis, biomedical and pharmaceutical investigations or even diagnostics.nIn this work, it was demonstrated that capillary micellar electrokinetic chromatography is an excellent toolnextremely helpful in investigations focused on prebiotic synthesis of molecules essential for formation of life onnearly Earth – nucleobases. In particular, rapid separation of nucleobases (< 2 min) was achieved in 40 mM boratenbuffer separation electrolyte containing 60 mM sodium dodecyl sulfate as an additive. This approach enabledndetection of nucleobases formed in thermolysed formamide under conditions simulating the environmentnoccurring on early Earth. Moreover, polydopamine-based molecularly imprinted polymers specific to thyminenand uracil improved detection of these low abundant products.

Název v anglickém jazyce

Micellar electrokinetic chromatography as a powerful analytical tool for research on prebiotic chemistry

Popis výsledku anglicky

Capillary electromigration techniques have proven their capabilities in detection of variety of analytes from inorganic ions and small organic molecules through bio(macro)molecules to large analytes such as cells or nano/ micro particles. Also broad range of potential applications includes food and environmental analysis, biomedical and pharmaceutical investigations or even diagnostics.nIn this work, it was demonstrated that capillary micellar electrokinetic chromatography is an excellent toolnextremely helpful in investigations focused on prebiotic synthesis of molecules essential for formation of life onnearly Earth – nucleobases. In particular, rapid separation of nucleobases (< 2 min) was achieved in 40 mM boratenbuffer separation electrolyte containing 60 mM sodium dodecyl sulfate as an additive. This approach enabledndetection of nucleobases formed in thermolysed formamide under conditions simulating the environmentnoccurring on early Earth. Moreover, polydopamine-based molecularly imprinted polymers specific to thyminenand uracil improved detection of these low abundant products.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10403 - Physical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Microchemical Journal

ISSN

0026-265X

e-ISSN

1095-9149

Svazek periodika

167

Číslo periodika v rámci svazku

AUG 2021

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

106022

Kód UT WoS článku

000662640500005

EID výsledku v databázi Scopus

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