Pro-healing protein release from 3D-printed „smart“ hydrogel carriers applicable in regenerative medicine
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F21%3APU142486" target="_blank" >RIV/00216305:26620/21:PU142486 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.mrs-serbia.org.rs/files/YUCOMAT-2021.pdf" target="_blank" >https://www.mrs-serbia.org.rs/files/YUCOMAT-2021.pdf</a>
DOI - Digital Object Identifier
—
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Pro-healing protein release from 3D-printed „smart“ hydrogel carriers applicable in regenerative medicine
Popis výsledku v původním jazyce
In recent years, there has been an increase in the use of 3D printing technologies in regenerative medicine to produce medical implants. This work deals with the 3D printing of a hydrogel carrier based on itaconyl-modified PLGA-PEG-PLGA thermosensitive copolymer, which can be crosslinked with blue light in the presence of a water-soluble nontoxic photoinitiator. The copolymer for 3D printing is water soluble, and bioresorbable in the human body. The printing process was performed by direct ink writing method at ambient temperature between 20-40 °C to avoid bioactive substances damage (e.g., growth factors) incorporated into the copolymer water solution before the printing process. A thermostable 9-point mutant of fibroblast growth factor 2 (FGF2-STAB®., Enantis L.t.d.) was chosen as the ideal bioactive component for its ability to support the growth and the formation of new vessels (angiogenesis), leading to improved wound healing, tissue regeneration and contributes to the pathogenesis of several di
Název v anglickém jazyce
Pro-healing protein release from 3D-printed „smart“ hydrogel carriers applicable in regenerative medicine
Popis výsledku anglicky
In recent years, there has been an increase in the use of 3D printing technologies in regenerative medicine to produce medical implants. This work deals with the 3D printing of a hydrogel carrier based on itaconyl-modified PLGA-PEG-PLGA thermosensitive copolymer, which can be crosslinked with blue light in the presence of a water-soluble nontoxic photoinitiator. The copolymer for 3D printing is water soluble, and bioresorbable in the human body. The printing process was performed by direct ink writing method at ambient temperature between 20-40 °C to avoid bioactive substances damage (e.g., growth factors) incorporated into the copolymer water solution before the printing process. A thermostable 9-point mutant of fibroblast growth factor 2 (FGF2-STAB®., Enantis L.t.d.) was chosen as the ideal bioactive component for its ability to support the growth and the formation of new vessels (angiogenesis), leading to improved wound healing, tissue regeneration and contributes to the pathogenesis of several di
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
—
OECD FORD obor
10404 - Polymer science
Návaznosti výsledku
Projekt
<a href="/cs/project/EF19_073%2F0016948" target="_blank" >EF19_073/0016948: Kvalitní interní granty VUT</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů