„Smart“ biodegradable hydrogel as carrier for pro-healing proteins applicable in regenerative medicine: synthesis, characterization and controlled release

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F21%3APU142383" target="_blank" >RIV/00216305:26620/21:PU142383 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.ecmconferences.org/abstracts/2021/Collection1/c1.html" target="_blank" >https://www.ecmconferences.org/abstracts/2021/Collection1/c1.html</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

„Smart“ biodegradable hydrogel as carrier for pro-healing proteins applicable in regenerative medicine: synthesis, characterization and controlled release

Popis výsledku v původním jazyce

There is a strong emphasis on controlled drug delivery systems at this time. In this work stable Fibroblast growth factor 2 (FGF2-stab), developed by the Enantis company (Brno, CZ), was used as a protein-based drug. FGF2-stab stimulates the growth and the development of new vessels (angiogenesis), leading to improved wound healing, tissue development and contributes to the pathogenesis of several diseases (cancer or atherosclerosis). Amphiphilic PLGA-PEG-PLGA triblock copolymer was used as the biodegradable water-soluble copolymer that undergoes to a gel at physiological temperature. Along with increasing temperature in an aqueous environment, the PLGA-PEG-PLGA copolymer forms micelles having the hydrophobic core (PLGA) and the hydrophilic shell surface (PEG). Nowadays, drug carriers based on PLGA-PEG-PLGA copolymers are already commercially available under the names ReGel® and OncoGel® loaded with insulin or paclitaxel, respectively.

Název v anglickém jazyce

„Smart“ biodegradable hydrogel as carrier for pro-healing proteins applicable in regenerative medicine: synthesis, characterization and controlled release

Popis výsledku anglicky

There is a strong emphasis on controlled drug delivery systems at this time. In this work stable Fibroblast growth factor 2 (FGF2-stab), developed by the Enantis company (Brno, CZ), was used as a protein-based drug. FGF2-stab stimulates the growth and the development of new vessels (angiogenesis), leading to improved wound healing, tissue development and contributes to the pathogenesis of several diseases (cancer or atherosclerosis). Amphiphilic PLGA-PEG-PLGA triblock copolymer was used as the biodegradable water-soluble copolymer that undergoes to a gel at physiological temperature. Along with increasing temperature in an aqueous environment, the PLGA-PEG-PLGA copolymer forms micelles having the hydrophobic core (PLGA) and the hydrophilic shell surface (PEG). Nowadays, drug carriers based on PLGA-PEG-PLGA copolymers are already commercially available under the names ReGel® and OncoGel® loaded with insulin or paclitaxel, respectively.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/EF19_073%2F0016948" target="_blank" >EF19_073/0016948: Kvalitní interní granty VUT</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů