Efficacy of Various Antimicrobial Agents Loaded in Resorbable Porous Bone Cement Useful in the Treatment of Osteomyelitis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F21%3APU142518" target="_blank" >RIV/00216305:26620/21:PU142518 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.ecmconferences.org/abstracts/2021/Collection1/c1.html" target="_blank" >https://www.ecmconferences.org/abstracts/2021/Collection1/c1.html</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Efficacy of Various Antimicrobial Agents Loaded in Resorbable Porous Bone Cement Useful in the Treatment of Osteomyelitis

Popis výsledku v původním jazyce

All surgeries carry the risk of complications due to bacterial infections. Infected hip or knee revisions are generally accompanied with local and systemic antibiotic therapy. Generally, in two-stage revisions, non- degradable poly(methyl methacrylate) spacers loaded with antibiotics are used. Only 3-5% of the antibiotic appears to be released during in vivo testing. To overcome this issue, we have developed a biodegradable, “self- setting”, thixotropic and osteoconductive bone cement based on polymer and calcium phosphate. In the presented work, we loaded the cement with either vancomycin or biogenic selenium nanoparticles (SeNPs) to compare their release and antimicrobial efficiency in vitro.

Název v anglickém jazyce

Efficacy of Various Antimicrobial Agents Loaded in Resorbable Porous Bone Cement Useful in the Treatment of Osteomyelitis

Popis výsledku anglicky

All surgeries carry the risk of complications due to bacterial infections. Infected hip or knee revisions are generally accompanied with local and systemic antibiotic therapy. Generally, in two-stage revisions, non- degradable poly(methyl methacrylate) spacers loaded with antibiotics are used. Only 3-5% of the antibiotic appears to be released during in vivo testing. To overcome this issue, we have developed a biodegradable, “self- setting”, thixotropic and osteoconductive bone cement based on polymer and calcium phosphate. In the presented work, we loaded the cement with either vancomycin or biogenic selenium nanoparticles (SeNPs) to compare their release and antimicrobial efficiency in vitro.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/NV18-05-00379" target="_blank" >NV18-05-00379: Vývoj a komplexní hodnocení nové injekčně aplikovatelné, resorbovatelné, porézní kostní náhrady s řízeným uvolňováním antimikrobiálních látek</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů