Plasma-coated PCL scaffolds with immobilized platelet-rich plasma enhance the wound healing in diabetics mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F22%3APU145065" target="_blank" >RIV/00216305:26620/22:PU145065 - isvavai.cz</a>

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1002/ppap.202200032" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/ppap.202200032</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ppap.202200032" target="_blank" >10.1002/ppap.202200032</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Plasma-coated PCL scaffolds with immobilized platelet-rich plasma enhance the wound healing in diabetics mice

Popis výsledku v původním jazyce

COOH plasma polymer layers deposited onto polycaprolactone (PCL) nanofibers by plasma polymerization of CO2 and C2H4 in the Ar atmosphere were obtained and tested for diabetic wound healing. Simply by changing the deposition time, very different morphologies of coated PCL nanofibers were achieved. In vivo tests revealed that by applying modified nanofibers for 10 days, wound healing accelerated by 32.1%. Compared to a controlled wound characterized by an acute inflammatory process, wounds covered with nanofibers with platelet-rich plasma demonstrated complete healing with a high percentage of collagen fibers on Day 19.

Název v anglickém jazyce

Plasma-coated PCL scaffolds with immobilized platelet-rich plasma enhance the wound healing in diabetics mice

Popis výsledku anglicky

COOH plasma polymer layers deposited onto polycaprolactone (PCL) nanofibers by plasma polymerization of CO2 and C2H4 in the Ar atmosphere were obtained and tested for diabetic wound healing. Simply by changing the deposition time, very different morphologies of coated PCL nanofibers were achieved. In vivo tests revealed that by applying modified nanofibers for 10 days, wound healing accelerated by 32.1%. Compared to a controlled wound characterized by an acute inflammatory process, wounds covered with nanofibers with platelet-rich plasma demonstrated complete healing with a high percentage of collagen fibers on Day 19.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10305 - Fluids and plasma physics (including surface physics)

Projekt

<a href="/cs/project/LM2018110" target="_blank" >LM2018110: Výzkumná infrastruktura CzechNanoLab</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Plasma Processes and Polymers

ISSN

1612-8850

e-ISSN

1612-8869

Svazek periodika

19

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

12

Strana od-do

„e2200032“-„“

Kód UT WoS článku

000776483500001

EID výsledku v databázi Scopus

2-s2.0-85127447803