Microrobots with Antimicrobial Peptide Nanoarchitectonics for the Eradication of Antibiotic-Resistant Biofilms

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F22%3APU145575" target="_blank" >RIV/00216305:26620/22:PU145575 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62156489:43210/22:43921874

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1002/adfm.202112935" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/adfm.202112935</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/adfm.202112935" target="_blank" >10.1002/adfm.202112935</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Microrobots with Antimicrobial Peptide Nanoarchitectonics for the Eradication of Antibiotic-Resistant Biofilms

Popis výsledku v původním jazyce

Bacterial biofilms are composed of a consortium of bacteria that communicate with each other through quorum sensing. Therefore, bacteria can form an extracellular matrix, which is a mucus composed of exopolysaccharides, peptidoglycans, and extracellular DNA, through these communication molecules. The matrix protects the community of bacteria from the adverse effects of the external environment, including antibiotics, biocides, and eradicating agents. Self-propelled functional microrobots offer great promises in the biomedical field. The self-propelled microrobots represent an innovative platform in microrobotic research, aiming to have an important role in the biomedical field. One of the potential applications is removal of bacterial biofilms. Herein, the specific design of multifunctional microrobots is demonstrated using antimicrobial-designed peptides for eradication of methicillin-resistant Staphylococcus aureus (MRSA)-produced biofilms. The designed microrobots can perform various tasks, including autonomous navigation toward bacterial cells, mechanical entry into bacterial biofilms, and blockage of the replication of bacterial DNA by indolicidin peptides. The implemented design extends the microrobot applications not only to the removal of biological aggregates but also to the delivery and release of drugs or even target manipulation, demonstrating their great potential for use in biomedical research.

Název v anglickém jazyce

Microrobots with Antimicrobial Peptide Nanoarchitectonics for the Eradication of Antibiotic-Resistant Biofilms

Popis výsledku anglicky

Bacterial biofilms are composed of a consortium of bacteria that communicate with each other through quorum sensing. Therefore, bacteria can form an extracellular matrix, which is a mucus composed of exopolysaccharides, peptidoglycans, and extracellular DNA, through these communication molecules. The matrix protects the community of bacteria from the adverse effects of the external environment, including antibiotics, biocides, and eradicating agents. Self-propelled functional microrobots offer great promises in the biomedical field. The self-propelled microrobots represent an innovative platform in microrobotic research, aiming to have an important role in the biomedical field. One of the potential applications is removal of bacterial biofilms. Herein, the specific design of multifunctional microrobots is demonstrated using antimicrobial-designed peptides for eradication of methicillin-resistant Staphylococcus aureus (MRSA)-produced biofilms. The designed microrobots can perform various tasks, including autonomous navigation toward bacterial cells, mechanical entry into bacterial biofilms, and blockage of the replication of bacterial DNA by indolicidin peptides. The implemented design extends the microrobot applications not only to the removal of biological aggregates but also to the delivery and release of drugs or even target manipulation, demonstrating their great potential for use in biomedical research.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Advanced Materials for Optics and Electronics

ISSN

1616-301X

e-ISSN

1616-3028

Svazek periodika

32

Číslo periodika v rámci svazku

43

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

11

Strana od-do

1-11

Kód UT WoS článku

000839921300001

EID výsledku v databázi Scopus

2-s2.0-85135832830