Beyond Karl Fischer titration: a monolithic quantum cascade sensor for monitoring residual water concentration in solvents

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F23%3APU148295" target="_blank" >RIV/00216305:26620/23:PU148295 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.rsc.org/en/content/articlelanding/2023/LC/D2LC00724J" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2023/LC/D2LC00724J</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/d2lc00724j" target="_blank" >10.1039/d2lc00724j</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Beyond Karl Fischer titration: a monolithic quantum cascade sensor for monitoring residual water concentration in solvents

Popis výsledku v původním jazyce

Quality control of liquids is an important part of analytical chemistry. The gold standard for measuring residual water in organic solvents and pharmaceutical applications is Karl Fischer titration. It has a high sensitivity, selectivity and accuracy. The downsides are a time-consuming offline analysis, together with the need for toxic reagents producing waste, and it suffers from poor inter-laboratory reproducibility. In this work, we present a high-performance lab-on-a-chip sensor exploiting mid-IR spectroscopy for liquid sensing. It is operating at 6.1 mu m wavelength and is suitable for robust and flexible real-time in situ analysis of the residual water concentration in isopropyl alcohol. This is demonstrated in two experiments. A custom-made 60 mu L flow cell is employed to measure only minute amounts of analyte in an inline configuration. In a second approach, the whole sensor is immersed into the analyte to demonstrate sensitive and rapid in situ operation on the millisecond time scale. This is confirmed by the ability for time resolved single water-droplet monitoring, while they are mixed into the liquid sample. We obtain a limit of detection between 120 ppm and 150 ppm with a concentration coverage spanning three orders of magnitude from 1.2 x 10(-2)%(vol) to 25%(vol) for the flow cell and 1.5 x 10(-2)%(vol) to 19%(vol) in the in situ configuration, respectively.

Název v anglickém jazyce

Beyond Karl Fischer titration: a monolithic quantum cascade sensor for monitoring residual water concentration in solvents

Popis výsledku anglicky

Quality control of liquids is an important part of analytical chemistry. The gold standard for measuring residual water in organic solvents and pharmaceutical applications is Karl Fischer titration. It has a high sensitivity, selectivity and accuracy. The downsides are a time-consuming offline analysis, together with the need for toxic reagents producing waste, and it suffers from poor inter-laboratory reproducibility. In this work, we present a high-performance lab-on-a-chip sensor exploiting mid-IR spectroscopy for liquid sensing. It is operating at 6.1 mu m wavelength and is suitable for robust and flexible real-time in situ analysis of the residual water concentration in isopropyl alcohol. This is demonstrated in two experiments. A custom-made 60 mu L flow cell is employed to measure only minute amounts of analyte in an inline configuration. In a second approach, the whole sensor is immersed into the analyte to demonstrate sensitive and rapid in situ operation on the millisecond time scale. This is confirmed by the ability for time resolved single water-droplet monitoring, while they are mixed into the liquid sample. We obtain a limit of detection between 120 ppm and 150 ppm with a concentration coverage spanning three orders of magnitude from 1.2 x 10(-2)%(vol) to 25%(vol) for the flow cell and 1.5 x 10(-2)%(vol) to 19%(vol) in the in situ configuration, respectively.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10600 - Biological sciences

Projekt

—

Návaznosti

—

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

LAB ON A CHIP

ISSN

1473-0197

e-ISSN

1473-0189

Svazek periodika

23

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

1816-1824

Kód UT WoS článku

000934626400001

EID výsledku v databázi Scopus

2-s2.0-85148674049