Biodegradable WE43 Mg alloy/hydroxyapatite interpenetrating phase composites with reduced hydrogen evolution

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F24%3APU152324" target="_blank" >RIV/00216305:26620/24:PU152324 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S2452199X24003876" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2452199X24003876</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bioactmat.2024.08.048" target="_blank" >10.1016/j.bioactmat.2024.08.048</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Biodegradable WE43 Mg alloy/hydroxyapatite interpenetrating phase composites with reduced hydrogen evolution

Popis výsledku v původním jazyce

Biodegradable magnesium implants offer a solution for bone repair without the need for implant removal. However, concerns persist regarding peri-implant gas accumulation, which has limited their widespread clinical acceptance. Consequently, there is a need to minimise the mass of magnesium to reduce the total volume of gas generated around the implants. Incorporating porosity is a direct approach to reducing the mass of the implants, but it also decreases the strength and degradation resistance. This study demonstrates that the infiltration of a calcium phosphate cement into an additively manufactured WE43 Mg alloy scaffold with 75 % porosity, followed by hydrothermal treatment, yields biodegradable magnesium/hydroxyapatite interpenetrating phase composites that generate an order of magnitude less hydrogen gas during degradation than WE43 scaffolds. The enhanced degradation resistance results from magnesium passivation, allowing osteoblast proliferation in indirect contact with composites. Additionally, the composites exhibit a compressive strength 1.8 times greater than that of the scaffolds, falling within the upper range of the compressive strength of cancellous bone. These results emphasise the potential of the new biodegradable interpenetrating phase composites for the fabrication of temporary osteosynthesis devices. Optimizing cement hardening and magnesium passivation during hydrothermal processing is crucial for achieving both high compressive strength and low degradation rate.

Název v anglickém jazyce

Biodegradable WE43 Mg alloy/hydroxyapatite interpenetrating phase composites with reduced hydrogen evolution

Popis výsledku anglicky

Biodegradable magnesium implants offer a solution for bone repair without the need for implant removal. However, concerns persist regarding peri-implant gas accumulation, which has limited their widespread clinical acceptance. Consequently, there is a need to minimise the mass of magnesium to reduce the total volume of gas generated around the implants. Incorporating porosity is a direct approach to reducing the mass of the implants, but it also decreases the strength and degradation resistance. This study demonstrates that the infiltration of a calcium phosphate cement into an additively manufactured WE43 Mg alloy scaffold with 75 % porosity, followed by hydrothermal treatment, yields biodegradable magnesium/hydroxyapatite interpenetrating phase composites that generate an order of magnitude less hydrogen gas during degradation than WE43 scaffolds. The enhanced degradation resistance results from magnesium passivation, allowing osteoblast proliferation in indirect contact with composites. Additionally, the composites exhibit a compressive strength 1.8 times greater than that of the scaffolds, falling within the upper range of the compressive strength of cancellous bone. These results emphasise the potential of the new biodegradable interpenetrating phase composites for the fabrication of temporary osteosynthesis devices. Optimizing cement hardening and magnesium passivation during hydrothermal processing is crucial for achieving both high compressive strength and low degradation rate.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

<a href="/cs/project/NW24-10-00195" target="_blank" >NW24-10-00195: Personalizovaná rekonstrukce kosti s rychlou osseointegrací a antibakteriální titanové implantáty po chirurgické resekci osteosarkomu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bioactive Materials

ISSN

2452-199X

e-ISSN

—

Svazek periodika

42

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

CN - Čínská lidová republika

Počet stran výsledku

12

Strana od-do

519-530

Kód UT WoS článku

001318263000001

EID výsledku v databázi Scopus

2-s2.0-85203454108