Tissue microRNAs as predictive markers for gastric cancer patients undergoing palliative chemotherapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F16%3A10323173" target="_blank" >RIV/00669806:_____/16:10323173 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11140/16:10323173

Výsledek na webu

<a href="http://dx.doi.org/10.3892/ijo.2016.3484" target="_blank" >http://dx.doi.org/10.3892/ijo.2016.3484</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/ijo.2016.3484" target="_blank" >10.3892/ijo.2016.3484</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Tissue microRNAs as predictive markers for gastric cancer patients undergoing palliative chemotherapy

Popis výsledku v původním jazyce

MicroRNAs have the potential to become valuable predictive markers for gastric cancer. Samples of biopsy tissue, routinely taken from gastric cancer patients undergoing pallia-tive chemotherapy, constitute suitable material for microRNA profiling with the aim of predicting the effect of chemotherapy. Our study group consisted of 54 patients, all of whom under-went palliative chemotherapy based on 5-fluorouracil (5-FU) or 5-FU in combination with platinum derivatives between 2000 and 2013. The expression of 29 selected microRNAs and genes BRCA1, ERCC1, RRM1 and TS, in gastric cancer tissue macrodissected from FFPE tissue samples, was measured by quantitative RT-PCR. The relationship between gene expres-sion levels and time to progression (TTP) and overall survival (OS) was analysed. In routinely available FFPE tissue samples, we found 6 miRNAs with a relation to TTP, which may serve as predictors of the effectiveness of palliative treatment in gastric cancer patients. These miRNAs could also help in deciding whether to indicate palliative chemotherapy.

Název v anglickém jazyce

Tissue microRNAs as predictive markers for gastric cancer patients undergoing palliative chemotherapy

Popis výsledku anglicky

MicroRNAs have the potential to become valuable predictive markers for gastric cancer. Samples of biopsy tissue, routinely taken from gastric cancer patients undergoing pallia-tive chemotherapy, constitute suitable material for microRNA profiling with the aim of predicting the effect of chemotherapy. Our study group consisted of 54 patients, all of whom under-went palliative chemotherapy based on 5-fluorouracil (5-FU) or 5-FU in combination with platinum derivatives between 2000 and 2013. The expression of 29 selected microRNAs and genes BRCA1, ERCC1, RRM1 and TS, in gastric cancer tissue macrodissected from FFPE tissue samples, was measured by quantitative RT-PCR. The relationship between gene expres-sion levels and time to progression (TTP) and overall survival (OS) was analysed. In routinely available FFPE tissue samples, we found 6 miRNAs with a relation to TTP, which may serve as predictors of the effectiveness of palliative treatment in gastric cancer patients. These miRNAs could also help in deciding whether to indicate palliative chemotherapy.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

—

Projekt

<a href="/cs/project/NT14227" target="_blank" >NT14227: Stanovení prediktivních faktorů pro léčebný efekt chemoterapie u nemocných s karcinomem žaludku</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Oncology

ISSN

1019-6439

e-ISSN

—

Svazek periodika

48

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

11

Strana od-do

2693-2703

Kód UT WoS článku

000375807900047

EID výsledku v databázi Scopus

2-s2.0-84964612274