Association of HLA-DRB1 and HLA-DQB1 with red-blood-cell alloimmunization in the Czech population

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F17%3A10366036" target="_blank" >RIV/00669806:_____/17:10366036 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00843989:_____/17:E0106071 RIV/61988987:17110/17:A1901ZFY

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1111/vox.12478/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/vox.12478/epdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/vox.12478" target="_blank" >10.1111/vox.12478</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Association of HLA-DRB1 and HLA-DQB1 with red-blood-cell alloimmunization in the Czech population

Popis výsledku v původním jazyce

Background and Objectives Alloimmune antibodies against red-blood-cell (RBC) antigens induced in susceptible individuals (responders) by transfusion, pregnancy or transplantation may have serious clinical consequences. The aim of this study was to investigate association of alloimmunization against selected RBC antigens with HLA-Class II. Materials and Methods A total of 230 responders (106 monoresponders and 124 multiresponders) were enrolled into the study. HLA-DRB1 and HLA-DQB1 variants were determined by PCR-SSO and their frequencies compared between the patients (patient subgroups) and 375 ethnically and regionally matched controls. Results Development of multiple RBC antibodies was associated with HLA-DRB1*15 and HLA-DQB1*06 allelic groups in the patients, with the relationship being particularly apparent in those with anti-C+D antibodies. Furthermore, DRB1*13 and DQB1*06 were more frequent in multiresponders with anti-E+c antibodies and DRB1*03 and DQB1*02 in those with anti-E+Cw. Conclusion For the first time, we confirmed the association of HLA-DRB1*15 with RBC antibody multiresponder status and found HLA-Class II associations for three frequent RBC antibody combinations. Our data support the concept that HLA restriction plays an important role in the response to RBC alloantigens.

Název v anglickém jazyce

Association of HLA-DRB1 and HLA-DQB1 with red-blood-cell alloimmunization in the Czech population

Popis výsledku anglicky

Background and Objectives Alloimmune antibodies against red-blood-cell (RBC) antigens induced in susceptible individuals (responders) by transfusion, pregnancy or transplantation may have serious clinical consequences. The aim of this study was to investigate association of alloimmunization against selected RBC antigens with HLA-Class II. Materials and Methods A total of 230 responders (106 monoresponders and 124 multiresponders) were enrolled into the study. HLA-DRB1 and HLA-DQB1 variants were determined by PCR-SSO and their frequencies compared between the patients (patient subgroups) and 375 ethnically and regionally matched controls. Results Development of multiple RBC antibodies was associated with HLA-DRB1*15 and HLA-DQB1*06 allelic groups in the patients, with the relationship being particularly apparent in those with anti-C+D antibodies. Furthermore, DRB1*13 and DQB1*06 were more frequent in multiresponders with anti-E+c antibodies and DRB1*03 and DQB1*02 in those with anti-E+Cw. Conclusion For the first time, we confirmed the association of HLA-DRB1*15 with RBC antibody multiresponder status and found HLA-Class II associations for three frequent RBC antibody combinations. Our data support the concept that HLA restriction plays an important role in the response to RBC alloantigens.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Vox Sanguinis

ISSN

0042-9007

e-ISSN

—

Svazek periodika

112

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

156-162

Kód UT WoS článku

000396892300008

EID výsledku v databázi Scopus

2-s2.0-85007545150