Association of multispecific red blood cell alloimmunization with HLA-Class II variants is related to Rh phenotypes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F21%3AE0108894" target="_blank" >RIV/00843989:_____/21:E0108894 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/21:73609647

Výsledek na webu

<a href="http://www.elis.sk/download_file.php?product_id=7115&session_id=ntii2ei8eapgcvj57kj07t8341" target="_blank" >http://www.elis.sk/download_file.php?product_id=7115&session_id=ntii2ei8eapgcvj57kj07t8341</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/BLL_2021_028" target="_blank" >10.4149/BLL_2021_028</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Association of multispecific red blood cell alloimmunization with HLA-Class II variants is related to Rh phenotypes

Popis výsledku v původním jazyce

Aim: It remains unclear, why only some patients form alloantibodies against foreign RBC antigens. Transfusion of red blood cell (RBC) products and pregnancy are the most relevant causes of immunization against RBC alloantigens. Here we investigated the relationship between RBC alloantibodies, Rh phenotype, and HLA phenotype among patients with multiple RBC alloantibodiesMETHODS: In a group of 124 multi-responders - including both pregnant women and transplant recipients - we analysed the distribution of HLA-Class II variants in subgroups of multi-responders to RBC alloantigens according to their Rh status. Results: As expected, the RhD-negative phenotype was overrepresented in our alloimmunized group (49.2 %) compared to in the general population. Importantly, HLA-DRB1*15 carriers were significantly overrepresented among D-negative multi-responders compared to D-positive multi-responders (Pc = 0.045). Furthermore, the linked HLA-DRB1*13, HLA-DQB1*06, and HLA-DQA1*01 variants were more frequent in individuals with the DCCee phenotype than in other RhD-positive phenotypes. Conclusion: Our present findings showed that RBC multispecific alloimmunization was associated with particular HLA-Class II variants based on Rh status (Tab. 3, Ref. 22).

Název v anglickém jazyce

Association of multispecific red blood cell alloimmunization with HLA-Class II variants is related to Rh phenotypes

Popis výsledku anglicky

Aim: It remains unclear, why only some patients form alloantibodies against foreign RBC antigens. Transfusion of red blood cell (RBC) products and pregnancy are the most relevant causes of immunization against RBC alloantigens. Here we investigated the relationship between RBC alloantibodies, Rh phenotype, and HLA phenotype among patients with multiple RBC alloantibodiesMETHODS: In a group of 124 multi-responders - including both pregnant women and transplant recipients - we analysed the distribution of HLA-Class II variants in subgroups of multi-responders to RBC alloantigens according to their Rh status. Results: As expected, the RhD-negative phenotype was overrepresented in our alloimmunized group (49.2 %) compared to in the general population. Importantly, HLA-DRB1*15 carriers were significantly overrepresented among D-negative multi-responders compared to D-positive multi-responders (Pc = 0.045). Furthermore, the linked HLA-DRB1*13, HLA-DQB1*06, and HLA-DQA1*01 variants were more frequent in individuals with the DCCee phenotype than in other RhD-positive phenotypes. Conclusion: Our present findings showed that RBC multispecific alloimmunization was associated with particular HLA-Class II variants based on Rh status (Tab. 3, Ref. 22).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bratislavské lekárske listy

ISSN

0006-9248

e-ISSN

1336-0345

Svazek periodika

122

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

5

Strana od-do

179-183

Kód UT WoS článku

000637613200003

EID výsledku v databázi Scopus

2-s2.0-85102106351