Angiogenesis in Ocular and Extraocular Sebaceous Carcinoma
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F19%3A10409406" target="_blank" >RIV/00669806:_____/19:10409406 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11140/19:10409406
Výsledek na webu
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Qcs3aVF80X" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Qcs3aVF80X</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2340/00015555-3342" target="_blank" >10.2340/00015555-3342</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Angiogenesis in Ocular and Extraocular Sebaceous Carcinoma
Popis výsledku v původním jazyce
To shed more light on the pathogenesis of sebaceous carcinoma, we analysed the expression of proteins related to angiogenesis in 18 ocular and 22 extraocular sebaceous carcinomas using a broad panel of immunohistochemical markers. To quantify the expression of D2-40, vascular endothelial growth factor, vascular endothelial growth factor receptor-2 and -3, we calculated a quantification score by considering the percentage of positive tumour cells (0=0%, 1=up to 1%, 2=2-10%, 3=11-50%, and 4=>50%) in relation to the staining intensity (0=negative, 1=low, 2=medium, and 3=strong). Additionally, lymphatic microvessel density in the D2-40 stained sections was counted. Vascular endothelial growth factor receptor-3 (quantification score 9.42 +- 2.94) was significantly more strongly expressed than vascular endothelial growth factor receptor-2 (quantification score 2.15 +- 2.42, p < 0.001). Furthermore, epidermal vascular endothelial growth factor expression was negatively correlated with the intratumoural lymphatic vessel density, and the ratio of small lymphatics to large lymphatics was much higher in intratumoural tissue than in paratumoural tissue and in intraindividual control tissue, suggesting a lymphangiogenetic potential of sebaceous carcinoma.
Název v anglickém jazyce
Angiogenesis in Ocular and Extraocular Sebaceous Carcinoma
Popis výsledku anglicky
To shed more light on the pathogenesis of sebaceous carcinoma, we analysed the expression of proteins related to angiogenesis in 18 ocular and 22 extraocular sebaceous carcinomas using a broad panel of immunohistochemical markers. To quantify the expression of D2-40, vascular endothelial growth factor, vascular endothelial growth factor receptor-2 and -3, we calculated a quantification score by considering the percentage of positive tumour cells (0=0%, 1=up to 1%, 2=2-10%, 3=11-50%, and 4=>50%) in relation to the staining intensity (0=negative, 1=low, 2=medium, and 3=strong). Additionally, lymphatic microvessel density in the D2-40 stained sections was counted. Vascular endothelial growth factor receptor-3 (quantification score 9.42 +- 2.94) was significantly more strongly expressed than vascular endothelial growth factor receptor-2 (quantification score 2.15 +- 2.42, p < 0.001). Furthermore, epidermal vascular endothelial growth factor expression was negatively correlated with the intratumoural lymphatic vessel density, and the ratio of small lymphatics to large lymphatics was much higher in intratumoural tissue than in paratumoural tissue and in intraindividual control tissue, suggesting a lymphangiogenetic potential of sebaceous carcinoma.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30109 - Pathology
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Acta Dermato-Venereologica
ISSN
0001-5555
e-ISSN
—
Svazek periodika
99
Číslo periodika v rámci svazku
13
Stát vydavatele periodika
SE - Švédské království
Počet stran výsledku
5
Strana od-do
1270-1274
Kód UT WoS článku
000505961800012
EID výsledku v databázi Scopus
2-s2.0-85076585754