HLA-G 5'URR regulatory polymorphisms are associated with the risk of developing gliomas

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F23%3A10443635" target="_blank" >RIV/00669806:_____/23:10443635 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11140/23:10443635

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=eh-MEy3S1J" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=eh-MEy3S1J</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/00207454.2021.1922401" target="_blank" >10.1080/00207454.2021.1922401</a>

Jazyk výsledku

angličtina

Název v původním jazyce

HLA-G 5'URR regulatory polymorphisms are associated with the risk of developing gliomas

Popis výsledku v původním jazyce

Background: Human leukocyte antigen G (HLA-G) belongs to non-classical MHC class I molecules that is involved in the suppression of immune response. As HLA-G plays important role in the maintenance of fetal tolerance, its overexpression has been associated with tumor progression. For the regulation of HLA-G levels, genetic variants within the 5&apos; upstream regulatory region (5&apos;URR) are of crucial importance. Our study aimed to analyze the association between 16 HLA-G 5&apos;URR variants, sHLA-G level and clinical variables in glioma patients. Methods: We investigated 59 patients with gliomas (mean age 54.70+-15.10 years) and 131 healthy controls (mean age 41.45+-9.75 years). Patient&apos;s blood was obtained on the day of surgical treatment. The HLA-G 5&apos;URR polymorphisms were typed by direct sequencing and the plasma level of sHLA-G assessed by ELISA. Results: Haploblock within HLA-G 5&apos;URR consisting of -762T, -716G, -689G, -666T, -633A, followed by -486C and -201A alleles were significantly more frequent in patients with gliomas than in the controls (p&lt;0.05). No correlation of HLA-G 5&apos;URR variants with sHLA-G plasma level was found. Analysis of HLA-G 5&apos;URR variants with main clinical variables in patients with grade IV gliomas revealed that haploblock carriers of -762CT, -716TG, -689AG, -666GT, -633GA, -486AC, -477GC, -201GA followed by -369AC carriers tend to have lower age at onset as compared to other genotype carriers (p=0.04). Conclusion: Our results suggest genetic association of HLA-G 5&apos;URR variants with risk of developing gliomas and possible contribution of HLA-G to disease pathology

Název v anglickém jazyce

HLA-G 5'URR regulatory polymorphisms are associated with the risk of developing gliomas

Popis výsledku anglicky

Background: Human leukocyte antigen G (HLA-G) belongs to non-classical MHC class I molecules that is involved in the suppression of immune response. As HLA-G plays important role in the maintenance of fetal tolerance, its overexpression has been associated with tumor progression. For the regulation of HLA-G levels, genetic variants within the 5&apos; upstream regulatory region (5&apos;URR) are of crucial importance. Our study aimed to analyze the association between 16 HLA-G 5&apos;URR variants, sHLA-G level and clinical variables in glioma patients. Methods: We investigated 59 patients with gliomas (mean age 54.70+-15.10 years) and 131 healthy controls (mean age 41.45+-9.75 years). Patient&apos;s blood was obtained on the day of surgical treatment. The HLA-G 5&apos;URR polymorphisms were typed by direct sequencing and the plasma level of sHLA-G assessed by ELISA. Results: Haploblock within HLA-G 5&apos;URR consisting of -762T, -716G, -689G, -666T, -633A, followed by -486C and -201A alleles were significantly more frequent in patients with gliomas than in the controls (p&lt;0.05). No correlation of HLA-G 5&apos;URR variants with sHLA-G plasma level was found. Analysis of HLA-G 5&apos;URR variants with main clinical variables in patients with grade IV gliomas revealed that haploblock carriers of -762CT, -716TG, -689AG, -666GT, -633GA, -486AC, -477GC, -201GA followed by -369AC carriers tend to have lower age at onset as compared to other genotype carriers (p=0.04). Conclusion: Our results suggest genetic association of HLA-G 5&apos;URR variants with risk of developing gliomas and possible contribution of HLA-G to disease pathology

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30109 - Pathology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Neuroscience

ISSN

0020-7454

e-ISSN

1563-5279

Svazek periodika

133

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

365-374

Kód UT WoS článku

000701573100001

EID výsledku v databázi Scopus

2-s2.0-85116075237