Hladiny HLA-G v séru a plasmě

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F06%3A00043123" target="_blank" >RIV/68378050:_____/06:00043123 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378050:_____/07:00085147

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

HLA-G levels in serum and plasma

Popis výsledku v původním jazyce

HLA-G is a non-classical HLA class-I gene product. There are four membrane-bound (HLA-G1 to -G4) and three soluble forms (HLA-G5 to -G7). HLA-G in the soluble form is found in the plasma, amniotic fluid, and cord blood of healthy individuals. Quantitative determination suggested that HLA-G levels are genetically controlled. We observed that when plasma and serum levels were measured for the same individual, HLA-G plasma values were almost invariably higher than those from serum. Our results suggest thatHLA-G is trapped and/or consumed during clot formation. The amount trapped within the clot is variable and inconsistent. To obtain values which reflect the true biological levels, it is therefore recommended that HLA-G should be determined in the plasma. If serum levels are determined, they should be compared with matched control sera. Conclusions concerning sera levels might be erroneous, because the true plasma level of the protein can be significantly higher.

Název v anglickém jazyce

HLA-G levels in serum and plasma

Popis výsledku anglicky

HLA-G is a non-classical HLA class-I gene product. There are four membrane-bound (HLA-G1 to -G4) and three soluble forms (HLA-G5 to -G7). HLA-G in the soluble form is found in the plasma, amniotic fluid, and cord blood of healthy individuals. Quantitative determination suggested that HLA-G levels are genetically controlled. We observed that when plasma and serum levels were measured for the same individual, HLA-G plasma values were almost invariably higher than those from serum. Our results suggest thatHLA-G is trapped and/or consumed during clot formation. The amount trapped within the clot is variable and inconsistent. To obtain values which reflect the true biological levels, it is therefore recommended that HLA-G should be determined in the plasma. If serum levels are determined, they should be compared with matched control sera. Conclusions concerning sera levels might be erroneous, because the true plasma level of the protein can be significantly higher.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Tissue Antigens

ISSN

0001-2815

e-ISSN

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Svazek periodika

67

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

DK - Dánské království

Počet stran výsledku

6

Strana od-do

111-116

Kód UT WoS článku

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EID výsledku v databázi Scopus

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