Comprehensive Review of Prevention and Management Strategies for Medication-related Osteonecrosis of the Jaw (MRONJ)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F25%3A10500468" target="_blank" >RIV/00669806:_____/25:10500468 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11140/25:10500468

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=WZ3ULK0B7g" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=WZ3ULK0B7g</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3290/j.ohpd.c_2169" target="_blank" >10.3290/j.ohpd.c_2169</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comprehensive Review of Prevention and Management Strategies for Medication-related Osteonecrosis of the Jaw (MRONJ)

Popis výsledku v původním jazyce

Purpose: To assess and classify the strategies employed in various dental specialities for the prevention and management of medication-related osteonecrosis of the jaw (MRONJ).Materials and Methods: A comprehensive literature review was conducted, acquiring studies sourced from Google Scholar and PubMed. The emphasis was on studies published in recent years, focusing on successful MRONJ prevention techniques across various dental specialties.Results: Four types of prevention were identified. Primary prevention strategies include optimizing oral hygiene, managing dental caries, and extraction of hopeless teeth in patients before starting antiresorptive or antiangiogenic medications, to reduce MRONJ risk. Secondary prevention techniques involve tailored approaches during procedures employed during different dental specialties aimed at reducing complications in susceptible patients. Tertiary prevention focuses on managing established MRONJ, aiming to relieve symptoms and prevent further deterioration. Quaternary prevention seeks to limit overmedicalisation and reduce risks associated with medications that contribute to MRONJ development.Conclusion: Primary prevention remains the prevention of choice in terms of minimising the possible incidence of MRONJ, while secondary and tertiary prevention strategies are vital for managing risks and improving outcomes in susceptible patients. Quaternary prevention requires more research focusing on reducing the incidence of underlying conditions such as osteoporosis and cancer, which are associated with MRONJ development.

Název v anglickém jazyce

Comprehensive Review of Prevention and Management Strategies for Medication-related Osteonecrosis of the Jaw (MRONJ)

Popis výsledku anglicky

Purpose: To assess and classify the strategies employed in various dental specialities for the prevention and management of medication-related osteonecrosis of the jaw (MRONJ).Materials and Methods: A comprehensive literature review was conducted, acquiring studies sourced from Google Scholar and PubMed. The emphasis was on studies published in recent years, focusing on successful MRONJ prevention techniques across various dental specialties.Results: Four types of prevention were identified. Primary prevention strategies include optimizing oral hygiene, managing dental caries, and extraction of hopeless teeth in patients before starting antiresorptive or antiangiogenic medications, to reduce MRONJ risk. Secondary prevention techniques involve tailored approaches during procedures employed during different dental specialties aimed at reducing complications in susceptible patients. Tertiary prevention focuses on managing established MRONJ, aiming to relieve symptoms and prevent further deterioration. Quaternary prevention seeks to limit overmedicalisation and reduce risks associated with medications that contribute to MRONJ development.Conclusion: Primary prevention remains the prevention of choice in terms of minimising the possible incidence of MRONJ, while secondary and tertiary prevention strategies are vital for managing risks and improving outcomes in susceptible patients. Quaternary prevention requires more research focusing on reducing the incidence of underlying conditions such as osteoporosis and cancer, which are associated with MRONJ development.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30208 - Dentistry, oral surgery and medicine

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Oral Health &amp; Preventive Dentistry

ISSN

1602-1622

e-ISSN

1757-9996

Svazek periodika

23

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

15

Strana od-do

403-417

Kód UT WoS článku

001549909800003

EID výsledku v databázi Scopus

2-s2.0-105013075756