Vztah exprese p27kip1 k výskytu genetických abnormit u negeneralizovaného karcinomu prostaty

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F07%3A00015024" target="_blank" >RIV/00843989:_____/07:00015024 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

<A >Molecularly Genetic Determination of Prognostic Factors of the Prostate Cancer and Their Relationships to Expression of Protein p27kip1

Popis výsledku v původním jazyce

Published studies on prostate carcinoma report a strong connection between the c-myc gene amplification and immunohistochemical overexpression of the Myc protein.It is assumed that excessive Myc protein expression causes degradation of protein p27 resulting in activationof the pathway of cyclin E/cyclin-dependent kinase 2 and cell proliferation.Since it is known that numerous chromosomal and genetic abnormalities are connected to prostate carcinoma progression, the aim of the study was to show whether anyrelation exists between protein p27 expression and various genetic abnormities. Given that in prostate carcinoma, chromosome 8 is most usually affected, deletions 8p22and amplifications of zone 8q24 being the most frequent chromosomal changes, these were the most appropriate ones for evaluation. Our findings are in complete accord with the literature. Degradation of protein p27 represented by expression in 0-25 % prevailed in a group of prostate cancers with a finding of chromosomal ch

Název v anglickém jazyce

<A >Molecularly Genetic Determination of Prognostic Factors of the Prostate Cancer and Their Relationships to Expression of Protein p27kip1

Popis výsledku anglicky

Published studies on prostate carcinoma report a strong connection between the c-myc gene amplification and immunohistochemical overexpression of the Myc protein.It is assumed that excessive Myc protein expression causes degradation of protein p27 resulting in activationof the pathway of cyclin E/cyclin-dependent kinase 2 and cell proliferation.Since it is known that numerous chromosomal and genetic abnormalities are connected to prostate carcinoma progression, the aim of the study was to show whether anyrelation exists between protein p27 expression and various genetic abnormities. Given that in prostate carcinoma, chromosome 8 is most usually affected, deletions 8p22and amplifications of zone 8q24 being the most frequent chromosomal changes, these were the most appropriate ones for evaluation. Our findings are in complete accord with the literature. Degradation of protein p27 represented by expression in 0-25 % prevailed in a group of prostate cancers with a finding of chromosomal ch

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neoplasma

ISSN

0028-2685

e-ISSN

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Svazek periodika

54

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

000246073300010

EID výsledku v databázi Scopus

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