Validation of sparse sampling strategies to estimate cyclosporine A area under the concentration-time curve using either a specific radioimmunoassay or high-performance liquid chromography method

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F10%3A00101521" target="_blank" >RIV/00843989:_____/10:00101521 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1097/FTD.0b013e3181ed59fe" target="_blank" >http://dx.doi.org/10.1097/FTD.0b013e3181ed59fe</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/FTD.0b013e3181ed59fe" target="_blank" >10.1097/FTD.0b013e3181ed59fe</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Validation of sparse sampling strategies to estimate cyclosporine A area under the concentration-time curve using either a specific radioimmunoassay or high-performance liquid chromography method

Popis výsledku v původním jazyce

Abstract: Introduction: Area under the concentration-time curve (AUC) has been advocated as a better parameter to monitor cyclosporine A than trough concentrations. Up to now, more than 100 equations to estimate AUC using a limited sampling strategy havebeen published, but not all have been validated. Material and Methods: Eight equations for AUC(0-12h) and two for AUC(0-8h) were validated. Concentrations of cyclosporine A were analyzed by high-performance liquid chromatography (HPLC) and a specific radioimmunoassay (RIA) method. Forty male renal transplant patients were included in the study. Blood samples were taken predose and at 0.5, 1, 1.5, 2, 3, 5, 8, and 12 hours after the morning dose when the patient was in steady state. The percentage prediction error (%pe) was used for an assessment of the performance of the equations. Mean %pe less than +/- 15% and absolute %pe less than 30% in 95% of predictions were considered to be acceptable. Other possibilities such as %pe less than 2

Název v anglickém jazyce

Validation of sparse sampling strategies to estimate cyclosporine A area under the concentration-time curve using either a specific radioimmunoassay or high-performance liquid chromography method

Popis výsledku anglicky

Abstract: Introduction: Area under the concentration-time curve (AUC) has been advocated as a better parameter to monitor cyclosporine A than trough concentrations. Up to now, more than 100 equations to estimate AUC using a limited sampling strategy havebeen published, but not all have been validated. Material and Methods: Eight equations for AUC(0-12h) and two for AUC(0-8h) were validated. Concentrations of cyclosporine A were analyzed by high-performance liquid chromatography (HPLC) and a specific radioimmunoassay (RIA) method. Forty male renal transplant patients were included in the study. Blood samples were taken predose and at 0.5, 1, 1.5, 2, 3, 5, 8, and 12 hours after the morning dose when the patient was in steady state. The percentage prediction error (%pe) was used for an assessment of the performance of the equations. Mean %pe less than +/- 15% and absolute %pe less than 30% in 95% of predictions were considered to be acceptable. Other possibilities such as %pe less than 2

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/1A8655" target="_blank" >1A8655: Nové možnosti TDM cyklosporinu A a jeho metabolitů po transplantaci ledvin</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Therapeutic drug monitoring

ISSN

0163-4356

e-ISSN

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Svazek periodika

32

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

586-593

Kód UT WoS článku

000282099700009

EID výsledku v databázi Scopus

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